A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage

TY - JOUR

T1 - A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage

AU - Feng, G Q

AU - Mareque-Rivas, J C

AU - Torres Martin De Rosales, Rafael

AU - Williams, N H

PY - 2005/10/5

Y1 - 2005/10/5

N2 - The activity of a Zn(II) complex of a tetradentate, tripodal ligand for catalyzing phosphodiester cleavage is enhanced 750-fold by introducing three hydrogen bond donors to the ligand. Inhibition studies show that the Zn−aqua complex is the kinetically active form and that it binds the transition state with a formal dissociation constant of 3 × 108 M-1. The effect of these ligand modifications on the transition-state affinity is comparable to the rate acceleration provided by the metal ion itself. Overall, this mononuclear complex is more active than the most reactive dinuclear Zn(II) complexes reported to date.

AB - The activity of a Zn(II) complex of a tetradentate, tripodal ligand for catalyzing phosphodiester cleavage is enhanced 750-fold by introducing three hydrogen bond donors to the ligand. Inhibition studies show that the Zn−aqua complex is the kinetically active form and that it binds the transition state with a formal dissociation constant of 3 × 108 M-1. The effect of these ligand modifications on the transition-state affinity is comparable to the rate acceleration provided by the metal ion itself. Overall, this mononuclear complex is more active than the most reactive dinuclear Zn(II) complexes reported to date.

U2 - 10.1021/ja054003t

DO - 10.1021/ja054003t

M3 - Article

SN - 0002-7863

VL - 127

SP - 13470

EP - 13471

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 39

M1 - N/A

ER -