King's College London

Funding Information: We are grateful to the Kaiser Permanente Northern California members who have generously agreed to participate in the Kaiser Permanente Research Program on Genes, Environment, and Health. Support for participant enrollment, survey completion, and biospecimen collection for the RPGEH was provided by the Robert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, the Ellison Medical Foundation, and Kaiser Permanente Community Benefit Programs. Genotyping of the GERA cohort was funded by a grant from the National Institute on Aging, National Institute of Mental Health, and National Institute of Health Common Fund (RC2 AG036607). H.C. and E.J. were supported by the National Eye Institute (NEI) grant R01 EY027004, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 DK116738 and by the National Cancer Institute (NCI) R01 CA241623. This work was also made possible in part by NIH-NEI EY002162—Core Grant for Vision Research, by the Research to Prevent Blindness Unrestricted Grant (UCSF, Ophthalmology). K.S.N. receives support from NEI grant EY022891, BrightFocus Foundation (G2019360), Marin Community Foundation-Kathlyn McPherson Masneri and Arno P. Masneri Fund, and That Man May See Inc. T.J.H. was supported by National Institutes of Aging (NIA) grant R21 AG046616. S.A.L. was supported by National Institutes of Health / National Eye Institute grants R01 EY021505 and EY029770 and D.A. was supported by a Knights Templar Pediatric Ophthalmology Career Starter Grant Award. We would like to thank the research participants and employees of 23andMe for making this work possible (see Supplementary Information for the full list of members of the 23andMe Research Team). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.