A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.

Sameer Jauhar; Danilo Arnone; David S. Baldwin; Michael A P Bloomfield; Michael D Browning; Anthony Cleare; Phillip  Corlett,; John Francis William Deakin; David Erritzoe; Cynthia Fu; Paolo Fusar-Poli; Guy M. Goodwin; Joseph Hayes; Robert Howard; Oliver. D. Howes; Mario F Juruena; Raymond W. Lam; Stephen M. Lawrie; R. Hamish McAllister-Williams; Steven Marwaha; David  Matuskey; Robert A. McCutcheon; David J. Nutt; Carmine Pariante; Toby Pillinger; Rajiv Radhakrishnan; James Rucker; Sudhakar  Selveraj

A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.

Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael A P Bloomfield, Michael D Browning, Anthony Cleare, Phillip Corlett,, John Francis William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver. D. Howes, Mario F Juruena, Raymond W. Lam, Stephen M. Lawrie, R. Hamish McAllister-Williams, Steven MarwahaDavid Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selveraj

Research output: Contribution to journal › Article › peer-review

Abstract

A recent “umbrella” review examined various biomarkers relating to the serotonin system,
and concluded there was no consistent evidence implicating serotonin in the
pathophysiology of depression. We present reasons for why this conclusion is overstated,
including methodological weaknesses in the review process, selective reporting of data,
over-simplification, and errors in the interpretation of neuropsychopharmacological
findings. We use the examples of tryptophan depletion and serotonergic molecular imaging,
the two research areas most relevant to the investigation of serotonin, to illustrate this.

Original language	English
Journal	Molecular Psychiatry
Publication status	Accepted/In press - 21 Apr 2023

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Embargo ends: 27/04/2024

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Jauhar, S., Arnone, D., Baldwin, D. S., Bloomfield, M. A. P., Browning, M. D., Cleare, A., Corlett, P., Deakin, J. F. W., Erritzoe, D., Fu, C., Fusar-Poli, P., Goodwin, G. M., Hayes, J., Howard, R., Howes, O. D., Juruena, M. F., Lam, R. W., Lawrie, S. M., McAllister-Williams, R. H., ... Selveraj, S. (Accepted/In press). A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression. Molecular Psychiatry.

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title = "A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.",

abstract = "A recent “umbrella” review examined various biomarkers relating to the serotonin system,and concluded there was no consistent evidence implicating serotonin in thepathophysiology of depression. We present reasons for why this conclusion is overstated,including methodological weaknesses in the review process, selective reporting of data,over-simplification, and errors in the interpretation of neuropsychopharmacologicalfindings. We use the examples of tryptophan depletion and serotonergic molecular imaging,the two research areas most relevant to the investigation of serotonin, to illustrate this.",

author = "Sameer Jauhar and Danilo Arnone and Baldwin, {David S.} and Bloomfield, {Michael A P} and Browning, {Michael D} and Anthony Cleare and Phillip Corlett, and Deakin, {John Francis William} and David Erritzoe and Cynthia Fu and Paolo Fusar-Poli and Goodwin, {Guy M.} and Joseph Hayes and Robert Howard and Howes, {Oliver. D.} and Juruena, {Mario F} and Lam, {Raymond W.} and Lawrie, {Stephen M.} and McAllister-Williams, {R. Hamish} and Steven Marwaha and David Matuskey and McCutcheon, {Robert A.} and Nutt, {David J.} and Carmine Pariante and Toby Pillinger and Rajiv Radhakrishnan and James Rucker and Sudhakar Selveraj",

year = "2023",

month = apr,

day = "21",

language = "English",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Springer Nature [academic journals on nature.com]",

}

Jauhar, S, Arnone, D, Baldwin, DS, Bloomfield, MAP, Browning, MD, Cleare, A, Corlett, P, Deakin, JFW, Erritzoe, D, Fu, C , Fusar-Poli, P, Goodwin, GM, Hayes, J, Howard, R, Howes, OD, Juruena, MF, Lam, RW, Lawrie, SM, McAllister-Williams, RH, Marwaha, S, Matuskey, D, McCutcheon, RA, Nutt, DJ, Pariante, C , Pillinger, T, Radhakrishnan, R, Rucker, J & Selveraj, S 2023, 'A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.', Molecular Psychiatry.

TY - JOUR

T1 - A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.

AU - Jauhar, Sameer

AU - Arnone, Danilo

AU - Baldwin, David S.

AU - Bloomfield, Michael A P

AU - Browning, Michael D

AU - Cleare, Anthony

AU - Corlett,, Phillip

AU - Deakin, John Francis William

AU - Erritzoe, David

AU - Fu, Cynthia

AU - Fusar-Poli, Paolo

AU - Goodwin, Guy M.

AU - Hayes, Joseph

AU - Howard, Robert

AU - Howes, Oliver. D.

AU - Juruena, Mario F

AU - Lam, Raymond W.

AU - Lawrie, Stephen M.

AU - McAllister-Williams, R. Hamish

AU - Marwaha, Steven

AU - Matuskey, David

AU - McCutcheon, Robert A.

AU - Nutt, David J.

AU - Pariante, Carmine

AU - Pillinger, Toby

AU - Radhakrishnan, Rajiv

AU - Rucker, James

AU - Selveraj, Sudhakar

PY - 2023/4/21

Y1 - 2023/4/21

N2 - A recent “umbrella” review examined various biomarkers relating to the serotonin system,and concluded there was no consistent evidence implicating serotonin in thepathophysiology of depression. We present reasons for why this conclusion is overstated,including methodological weaknesses in the review process, selective reporting of data,over-simplification, and errors in the interpretation of neuropsychopharmacologicalfindings. We use the examples of tryptophan depletion and serotonergic molecular imaging,the two research areas most relevant to the investigation of serotonin, to illustrate this.

AB - A recent “umbrella” review examined various biomarkers relating to the serotonin system,and concluded there was no consistent evidence implicating serotonin in thepathophysiology of depression. We present reasons for why this conclusion is overstated,including methodological weaknesses in the review process, selective reporting of data,over-simplification, and errors in the interpretation of neuropsychopharmacologicalfindings. We use the examples of tryptophan depletion and serotonergic molecular imaging,the two research areas most relevant to the investigation of serotonin, to illustrate this.

M3 - Article

SN - 1359-4184

JO - Molecular Psychiatry

JF - Molecular Psychiatry

ER -

A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.

Abstract

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