A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.

Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael A P Bloomfield, Michael D Browning, Anthony Cleare, Phillip Corlett,, John Francis William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver. D. Howes, Mario F Juruena, Raymond W. Lam, Stephen M. Lawrie, R. Hamish McAllister-Williams, Steven MarwahaDavid Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selveraj

Research output: Contribution to journalArticlepeer-review

Abstract

A recent “umbrella” review examined various biomarkers relating to the serotonin system,
and concluded there was no consistent evidence implicating serotonin in the
pathophysiology of depression. We present reasons for why this conclusion is overstated,
including methodological weaknesses in the review process, selective reporting of data,
over-simplification, and errors in the interpretation of neuropsychopharmacological
findings. We use the examples of tryptophan depletion and serotonergic molecular imaging,
the two research areas most relevant to the investigation of serotonin, to illustrate this.
Original languageEnglish
JournalMolecular Psychiatry
Publication statusAccepted/In press - 21 Apr 2023

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