Research output: Contribution to journal › Article › peer-review
Dominik J Vogel, Federico Formenti, Andrew Retter, Francesco Vasques, Luigi Camporota
Original language | English |
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Pages (from-to) | 390-393 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 191 |
Issue number | 3 |
DOIs | |
Accepted/In press | 4 Sep 2020 |
Published | 1 Nov 2020 |
Additional links |
VogelDJ ODC_LeftShiftCOVID AcceptedMs
VogelDJ_ODC_LeftShiftCOVID_AcceptedMs.pdf, 1.31 MB, application/pdf
Uploaded date:07 Sep 2020
Version:Accepted author manuscript
Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb–O 2) affinity. Calculated oxygen tension at half-saturation (p 50) was on average (±SD) 3·3 (3·13) mmHg lower than the normal p 50 value (23·4 vs. 26·7 mmHg; P < 0·0001). Compared to an unmatched historic control of patients with other causes of severe respiratory failure, patients with COVID-19 had a significantly higher Hb–O 2 affinity (mean [SD] p 50 23·4 [3·13] vs. 24·6 [5.4] mmHg; P < 0·0001). We hypothesise that, due to the long disease process, acclimatisation to hypoxaemia could play a role.
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