A new chemical sensor for cellular imaging of NO is presented. This cell-permeable probe is based on a complex where copper(ii) is coordinated to a tridentate ligand substituted with a fluorophore (NBD) and an octyl group. The fluorescence response of this complex towards a range of reactive species (namely NO, NO2 , NO3 , H2O2, ClO, O2 and ONOO) has been studied in vitro showing that the probe is highly selective for NO. The probe is readily taken up by cells and is able to image the cellular concentrations of NO.

Original languageEnglish
Pages (from-to)18177-18182
Number of pages6
JournalDalton transactions (Cambridge, England : 2003)
Issue number45
Early online date18 Oct 2016
Publication statusE-pub ahead of print - 18 Oct 2016


Dive into the research topics of 'A lipophilic copper(II) complex as an optical probe for intracellular detection of NO'. Together they form a unique fingerprint.

Cite this