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A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

Research output: Contribution to journalArticle

Standard

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. / Okwuosa, Tochukwu C; Stefaniak, Dominika; Arafat, Basel; Isreb, Abdullah; Wan, Ka-Wai; Alhnan, Mohamed A.

In: Pharmaceutical Research, Vol. 33, No. 11, 11.2016, p. 2704-2712.

Research output: Contribution to journalArticle

Harvard

Okwuosa, TC, Stefaniak, D, Arafat, B, Isreb, A, Wan, K-W & Alhnan, MA 2016, 'A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets', Pharmaceutical Research, vol. 33, no. 11, pp. 2704-2712. https://doi.org/10.1007/s11095-016-1995-0

APA

Okwuosa, T. C., Stefaniak, D., Arafat, B., Isreb, A., Wan, K-W., & Alhnan, M. A. (2016). A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. Pharmaceutical Research, 33(11), 2704-2712. https://doi.org/10.1007/s11095-016-1995-0

Vancouver

Okwuosa TC, Stefaniak D, Arafat B, Isreb A, Wan K-W, Alhnan MA. A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. Pharmaceutical Research. 2016 Nov;33(11):2704-2712. https://doi.org/10.1007/s11095-016-1995-0

Author

Okwuosa, Tochukwu C ; Stefaniak, Dominika ; Arafat, Basel ; Isreb, Abdullah ; Wan, Ka-Wai ; Alhnan, Mohamed A. / A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. In: Pharmaceutical Research. 2016 ; Vol. 33, No. 11. pp. 2704-2712.

Bibtex Download

@article{8b9806d100664712b430abef8c4517e2,
title = "A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets",
abstract = "PURPOSE: The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.METHODS: Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a caplet-shaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of the drugs and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.RESULTS: Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication of immediate release tablets at temperatures as low as 110°C. The integrity of two model drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern.CONCLUSIONS: Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.",
keywords = "Dipyridamole/chemistry, Drug Liberation, Excipients/chemistry, Humans, Povidone/chemistry, Printing, Three-Dimensional, Solubility, Tablets/chemistry, Technology, Pharmaceutical, Temperature, Theophylline/chemistry",
author = "Okwuosa, {Tochukwu C} and Dominika Stefaniak and Basel Arafat and Abdullah Isreb and Ka-Wai Wan and Alhnan, {Mohamed A}",
year = "2016",
month = nov,
doi = "10.1007/s11095-016-1995-0",
language = "English",
volume = "33",
pages = "2704--2712",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer New York",
number = "11",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

AU - Okwuosa, Tochukwu C

AU - Stefaniak, Dominika

AU - Arafat, Basel

AU - Isreb, Abdullah

AU - Wan, Ka-Wai

AU - Alhnan, Mohamed A

PY - 2016/11

Y1 - 2016/11

N2 - PURPOSE: The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.METHODS: Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a caplet-shaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of the drugs and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.RESULTS: Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication of immediate release tablets at temperatures as low as 110°C. The integrity of two model drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern.CONCLUSIONS: Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

AB - PURPOSE: The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.METHODS: Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a caplet-shaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of the drugs and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.RESULTS: Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication of immediate release tablets at temperatures as low as 110°C. The integrity of two model drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern.CONCLUSIONS: Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

KW - Dipyridamole/chemistry

KW - Drug Liberation

KW - Excipients/chemistry

KW - Humans

KW - Povidone/chemistry

KW - Printing, Three-Dimensional

KW - Solubility

KW - Tablets/chemistry

KW - Technology, Pharmaceutical

KW - Temperature

KW - Theophylline/chemistry

U2 - 10.1007/s11095-016-1995-0

DO - 10.1007/s11095-016-1995-0

M3 - Article

C2 - 27506424

VL - 33

SP - 2704

EP - 2712

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 11

ER -

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