TY - JOUR
T1 - A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults
T2 - A Case–Control Analysis Nested within the Three-City Cohort Study
AU - Tor-Roca, Alba
AU - Sánchez-Pla, Alex
AU - Korosi, Aniko
AU - Pallàs, Mercè
AU - Lucassen, Paul J.
AU - Castellano-Escuder, Pol
AU - Aigner, Ludwig
AU - González-Domínguez, Raúl
AU - Manach, Claudine
AU - Carmona, Francisco
AU - Vegas, Esteban
AU - Helmer, Catherine
AU - Feart, Catherine
AU - Lefèvre-Arbogast, Sophie
AU - Neuffer, Jeanne
AU - Lee, Hyunah
AU - Thuret, Sandrine
AU - Andres-Lacueva, Cristina
AU - Samieri, Cécilia
AU - Urpi-Sarda, Mireia
N1 - Publisher Copyright:
© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
PY - 2024/7
Y1 - 2024/7
N2 - Scope: Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. Methods and results: This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80–1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83–1.01]; p = 0.084). Conclusions: A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.
AB - Scope: Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. Methods and results: This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80–1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83–1.01]; p = 0.084). Conclusions: A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.
KW - aging
KW - Alzheimer's disease
KW - cognitive dysfunction
KW - cognitive impairment
KW - metabolite
UR - http://www.scopus.com/inward/record.url?scp=85174588287&partnerID=8YFLogxK
U2 - 10.1002/mnfr.202300271
DO - 10.1002/mnfr.202300271
M3 - Article
C2 - 37876144
AN - SCOPUS:85174588287
SN - 1613-4125
VL - 68
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 13
M1 - 2300271
ER -