A meta-analysis of gene (5-HTT) × environment interactions in eating pathology using secondary data analyses: Abstracts of the 24rd European Congress of Psychiatry

TY - JOUR

T1 - A meta-analysis of gene (5-HTT) × environment interactions in eating pathology using secondary data analyses

T2 - Abstracts of the 24rd European Congress of Psychiatry

AU - Rozenblat, V.

AU - Ng, D.

AU - Fuller-Tyszkiewicz, M.

AU - Akkermann, K.

AU - Collier, D.

AU - Engels, R.

AU - Fernandez-Aranda, F.

AU - Harro, J.

AU - Karwautz, A.

AU - Homberg, J.

AU - Klump, K.

AU - Racine, S.

AU - Larson, C.

AU - Steiger, H.

AU - Richardson, J.

AU - Stoltenberg, S.

AU - van Strien, T.

AU - Wagner, G.

AU - Treasure, J.

AU - Krug, I.

PY - 2016/3

Y1 - 2016/3

N2 - BackgroundGene × environment (G × E) interactions in eating pathology have been increasingly investigated, however studies have been limited by sample size due to the difficulty of obtaining genetic data.ObjectiveTo synthesize existing G × E research in the eating disorders (ED) field and provide a clear picture of the current state of knowledge with analyses of larger samples.MethodComplete data from seven studies investigating community (n = 1750, 64.5% female) and clinical (n = 426, 100% female) populations, identified via systematic review, were included. Data were combined to perform five analyses: 5-HTTLPR × Traumatic Life Events (0–17 events) to predict ED status (n = 909), 5-HTTLPR × Sexual and Physical Abuse (n = 1097) to predict bulimic symptoms, 5-HTLPR × Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR × Impulsivity to predict disordered eating (n = 1149).ResultsThe low function (s) allele of 5-HTTLPR interacted with number of traumatic life events (P < .01) and sexual and physical abuse (P < .05) to predict increased likelihood of an ED in females but not males (Fig. 1). No other G × E interactions were significant, possibly due to the medium to low compatibility between datasets (Fig. 1).ConclusionEarly promising results suggest that increased knowledge of G × E interactions could be achieved if studies increased uniformity of measuring ED and environmental variables, allowing for continued collaboration to overcome the restrictions of obtaining genetic samples.

AB - BackgroundGene × environment (G × E) interactions in eating pathology have been increasingly investigated, however studies have been limited by sample size due to the difficulty of obtaining genetic data.ObjectiveTo synthesize existing G × E research in the eating disorders (ED) field and provide a clear picture of the current state of knowledge with analyses of larger samples.MethodComplete data from seven studies investigating community (n = 1750, 64.5% female) and clinical (n = 426, 100% female) populations, identified via systematic review, were included. Data were combined to perform five analyses: 5-HTTLPR × Traumatic Life Events (0–17 events) to predict ED status (n = 909), 5-HTTLPR × Sexual and Physical Abuse (n = 1097) to predict bulimic symptoms, 5-HTLPR × Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR × Impulsivity to predict disordered eating (n = 1149).ResultsThe low function (s) allele of 5-HTTLPR interacted with number of traumatic life events (P < .01) and sexual and physical abuse (P < .05) to predict increased likelihood of an ED in females but not males (Fig. 1). No other G × E interactions were significant, possibly due to the medium to low compatibility between datasets (Fig. 1).ConclusionEarly promising results suggest that increased knowledge of G × E interactions could be achieved if studies increased uniformity of measuring ED and environmental variables, allowing for continued collaboration to overcome the restrictions of obtaining genetic samples.

U2 - 10.1016/j.eurpsy.2016.01.035

DO - 10.1016/j.eurpsy.2016.01.035

M3 - Meeting abstract

SN - 0924-9338

VL - 33

SP - S83

JO - European Psychiatry

JF - European Psychiatry

IS - Supplement

ER -