A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions.

Agnieszka  Gidziela; Yasmin Ahmadzadeh; Giorgia Michelini; Andrea G. Allegrini; Jessica Agnew-blais; Lok Yan Lau; Megan Duret; Francesca Procopio; Angelica Ronald; Kaili  Rimfeld; Margherita Malanchini

doi:doi.org/10.1101/2022.02.17.22271089

A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions.

Agnieszka Gidziela, Yasmin Ahmadzadeh, Giorgia Michelini, Andrea G. Allegrini, Jessica Agnew-blais, Lok Yan Lau, Megan Duret, Francesca Procopio, Angelica Ronald, Kaili Rimfeld, Margherita Malanchini

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

Abstract

A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs), their co-occurrence, and co-occurrence with other conditions during childhood and adolescence remains incomplete. This meta-analysis bridges gaps in our knowledge. First, we meta-analysed the literature on the relative contribution of genetic and environmental factors to NDDs. Second, we considered the literature on the overlap between different NDD categories. Lastly, we synthesized the literature on the co-occurrence between NDDs and disruptive, impulse control and conduct disorders (DICCs). We performed multilevel, random-effects meta-analyses on 296 independent studies, including over 4 million children and adolescents. We found all NDDs to be substantially heritable (family-based heritability (h2) = 0.66; SNP h2 = 0.19). Meta-analytic genetic correlations between NDDs, and between NDDs and DICCs were moderate to strong. However, given the paucity of available studies covering the co-occurrence of NDDs and DICCs, these could only be estimated for a few disorders. While our work provides direct evidence to inform and potentially guide clinical and educational diagnostic procedures and practice, it also highlights the imbalance in the research effort that has characterized developmental genetics research.

Original language	English
Journal	Nature Human Behaviour
DOIs	https://doi.org/doi.org/10.1101/2022.02.17.22271089 https://doi.org/10.1038/s41562-023-01530-y
Publication status	Published - 20 Feb 2023

Access to Document

doi.org/10.1101/2022.02.17.22271089Licence: CC BY
https://doi.org/10.1038/s41562-023-01530-yLicence: CC BY

Cite this

Gidziela, A., Ahmadzadeh, Y., Michelini, G., Allegrini, A. G., Agnew-blais, J., Lau, L. Y., Duret, M., Procopio, F., Ronald, A., Rimfeld, K., & Malanchini, M. (2023). A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions. Nature Human Behaviour. https://doi.org/doi.org/10.1101/2022.02.17.22271089, https://doi.org/10.1038/s41562-023-01530-y

@article{353153cb18a6407f90de9bbc17b4b2e9,

title = "A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions.",

abstract = "A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs), their co-occurrence, and co-occurrence with other conditions during childhood and adolescence remains incomplete. This meta-analysis bridges gaps in our knowledge. First, we meta-analysed the literature on the relative contribution of genetic and environmental factors to NDDs. Second, we considered the literature on the overlap between different NDD categories. Lastly, we synthesized the literature on the co-occurrence between NDDs and disruptive, impulse control and conduct disorders (DICCs). We performed multilevel, random-effects meta-analyses on 296 independent studies, including over 4 million children and adolescents. We found all NDDs to be substantially heritable (family-based heritability (h2) = 0.66; SNP h2 = 0.19). Meta-analytic genetic correlations between NDDs, and between NDDs and DICCs were moderate to strong. However, given the paucity of available studies covering the co-occurrence of NDDs and DICCs, these could only be estimated for a few disorders. While our work provides direct evidence to inform and potentially guide clinical and educational diagnostic procedures and practice, it also highlights the imbalance in the research effort that has characterized developmental genetics research.",

author = "Agnieszka Gidziela and Yasmin Ahmadzadeh and Giorgia Michelini and Allegrini, {Andrea G.} and Jessica Agnew-blais and Lau, {Lok Yan} and Megan Duret and Francesca Procopio and Angelica Ronald and Kaili Rimfeld and Margherita Malanchini",

year = "2023",

month = feb,

day = "20",

doi = "doi.org/10.1101/2022.02.17.22271089",

language = "English",

journal = "Nature Human Behaviour",

issn = "2397-3374",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions.

AU - Gidziela, Agnieszka

AU - Ahmadzadeh, Yasmin

AU - Michelini, Giorgia

AU - Allegrini, Andrea G.

AU - Agnew-blais, Jessica

AU - Lau, Lok Yan

AU - Duret, Megan

AU - Procopio, Francesca

AU - Ronald, Angelica

AU - Rimfeld, Kaili

AU - Malanchini, Margherita

PY - 2023/2/20

Y1 - 2023/2/20

N2 - A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs), their co-occurrence, and co-occurrence with other conditions during childhood and adolescence remains incomplete. This meta-analysis bridges gaps in our knowledge. First, we meta-analysed the literature on the relative contribution of genetic and environmental factors to NDDs. Second, we considered the literature on the overlap between different NDD categories. Lastly, we synthesized the literature on the co-occurrence between NDDs and disruptive, impulse control and conduct disorders (DICCs). We performed multilevel, random-effects meta-analyses on 296 independent studies, including over 4 million children and adolescents. We found all NDDs to be substantially heritable (family-based heritability (h2) = 0.66; SNP h2 = 0.19). Meta-analytic genetic correlations between NDDs, and between NDDs and DICCs were moderate to strong. However, given the paucity of available studies covering the co-occurrence of NDDs and DICCs, these could only be estimated for a few disorders. While our work provides direct evidence to inform and potentially guide clinical and educational diagnostic procedures and practice, it also highlights the imbalance in the research effort that has characterized developmental genetics research.

AB - A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs), their co-occurrence, and co-occurrence with other conditions during childhood and adolescence remains incomplete. This meta-analysis bridges gaps in our knowledge. First, we meta-analysed the literature on the relative contribution of genetic and environmental factors to NDDs. Second, we considered the literature on the overlap between different NDD categories. Lastly, we synthesized the literature on the co-occurrence between NDDs and disruptive, impulse control and conduct disorders (DICCs). We performed multilevel, random-effects meta-analyses on 296 independent studies, including over 4 million children and adolescents. We found all NDDs to be substantially heritable (family-based heritability (h2) = 0.66; SNP h2 = 0.19). Meta-analytic genetic correlations between NDDs, and between NDDs and DICCs were moderate to strong. However, given the paucity of available studies covering the co-occurrence of NDDs and DICCs, these could only be estimated for a few disorders. While our work provides direct evidence to inform and potentially guide clinical and educational diagnostic procedures and practice, it also highlights the imbalance in the research effort that has characterized developmental genetics research.

U2 - doi.org/10.1101/2022.02.17.22271089

DO - doi.org/10.1101/2022.02.17.22271089

M3 - Article

SN - 2397-3374

JO - Nature Human Behaviour

JF - Nature Human Behaviour

ER -

A meta-analysis of genetic effects on neurodevelopmental disorders and co-occurring conditions.

Abstract

Access to Document

Fingerprint

Cite this