Abstract
A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
Original language | English |
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Pages (from-to) | 156-161 |
Number of pages | 6 |
Journal | ORGANIC AND BIOMOLECULAR CHEMISTRY |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - 7 Jan 2021 |