A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Silvia Anselmi, Siyu Liu, Seong Heun Kim, Sarah M. Barry, Thomas S. Moody, Daniele Castagnolo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalORGANIC AND BIOMOLECULAR CHEMISTRY
Volume19
Issue number1
DOIs
Publication statusPublished - 7 Jan 2021

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