A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Silvia Anselmi; Siyu Liu; Seong Heun Kim; Sarah M. Barry; Thomas S. Moody; Daniele Castagnolo

doi:10.1039/d0ob01966f

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Silvia Anselmi, Siyu Liu, Seong Heun Kim, Sarah M. Barry, Thomas S. Moody, Daniele Castagnolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

Original language	English
Pages (from-to)	156-161
Number of pages	6
Journal	ORGANIC AND BIOMOLECULAR CHEMISTRY
Volume	19
Issue number	1
DOIs	https://doi.org/10.1039/d0ob01966f
Publication status	Published - 7 Jan 2021

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abstract = "A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.",

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AU - Anselmi, Silvia

AU - Liu, Siyu

AU - Kim, Seong Heun

AU - Barry, Sarah M.

AU - Moody, Thomas S.

AU - Castagnolo, Daniele

PY - 2021/1/7

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AB - A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

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A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Abstract

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