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A modelling study to evaluate the costs and effects of lowering the starting age of population breast cancer screening

Research output: Contribution to journalArticlepeer-review

Rositsa G. Koleva-Kolarova, Alicja M. Daszczuk, Chris de Jonge, Mohd Kahlil Abu Hantash, Zhuozhao Z. Zhan, Erik Jan Postema, Talitha L. Feenstra, Ruud M. Pijnappel, Marcel J.W. Greuter, Geertruida H. de Bock

Original languageEnglish
Pages (from-to)81-88
JournalMaturitas
Volume109
Early online date15 Dec 2017
DOIs
Accepted/In press8 Dec 2017
E-pub ahead of print15 Dec 2017
PublishedMar 2018

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Abstract

Background
Because the incidence of breast cancer increases between 45 and 50 years of age, a reconsideration is required of the current starting age (typically 50 years) for routine mammography. Our aim was to evaluate the quantitative benefits, harms, and cost-effectiveness of lowering the starting age of breast cancer screening in the Dutch general population.

Methods
Economic modelling with a lifelong perspective compared biennial screening for women aged 48–74 years and for women aged 46–74 years with the current Dutch screening programme, which screen women between the ages of 50 and 74 years. Tumour deaths prevented, years of life saved (YOLS), false-positive rates, radiation-induced tumours, costs and incremental cost-effectiveness ratios (ICERs) were evaluated.

Results
Starting the screening at 48 instead of 50 years of age led to increases in: the number of small tumours detected (4.0%), tumour deaths prevented (5.6%), false positives (9.2%), YOLS (5.6%), radiation-induced tumours (14.7%), and costs (4.1%). Starting the screening at 46 instead of 48 years of age increased the number of small tumours detected (3.3%), tumour deaths prevented (4.2%), false positives (8.8%), YOLS (3.7%), radiation-induced tumours (15.2%), and costs (4.0%). The ICER was €5,600/YOLS for the 48–74 scenario and €5,600/YOLS for the 46–74 scenario.

Conclusions
Women could benefit from lowering the starting age of screening as more breast cancer deaths would be averted. Starting regular breast cancer screening earlier is also cost-effective. As the number of additional expected harms is relatively small in both the scenarios examined, and the difference in ICERs is not large, introducing two additional screening rounds is justifiable.

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