A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

TY - JOUR

T1 - A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

AU - White, James R.

AU - Price, Gareth J.

AU - Schiffers, Stefanie

AU - Raithby, Paul R.

AU - Plucinski, Pawel K.

AU - Frost, Christopher G.

N1 - Funding Information: We are grateful to the EPSRC for funding. Dr. Stephen Flower is thanked for helpful discussions.

PY - 2010/7/28

Y1 - 2010/7/28

N2 - The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

AB - The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

UR - http://www.scopus.com/inward/record.url?scp=77953687035&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2010.05.104

DO - 10.1016/j.tetlet.2010.05.104

M3 - Article

AN - SCOPUS:77953687035

SN - 0040-4039

VL - 51

SP - 3913

EP - 3917

JO - TETRAHEDRON LETTERS

JF - TETRAHEDRON LETTERS

IS - 30

ER -