A mouse model to study reparative dentinogenesis

R. C. Babb, D. Chandrasekaran, L. K. Zaugg, P. T. Sharpe*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Citations (Scopus)


Different animal models have been introduced recently to study the process of reparative dentinogenesis in response to injury-induced pulp exposure. Using a mouse model is advantageous over other animal models since mice can be genetically manipulated to examine specific cellular pathways and lineage trace the progeny of a single cell. However, enabling a standardized molar damage in mice is demanding due to the small size of the teeth compared to the available dental instruments. Here we describe a reproducible and reliable in vivo model that allows us to study dentinogenesis in the first maxillary mouse molar.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc
Number of pages9
Publication statusPublished - 1 Jan 2019

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Dentinogenesis
  • In vivo
  • Molar damage
  • Mouse model
  • Tooth repair


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