A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer

Francesco Mesa; Maria Jose Mesa-Lopez; Juan Egea-Valenzuela; Cristina Benavides-Reyes; Luigi Nibali; Mark Ide; Giuseppe Mainas; Manfredi Rizzo; Antonio Magan-Fernandex

doi:10.3390/medicina58040546

A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer

Francesco Mesa, Maria Jose Mesa-Lopez, Juan Egea-Valenzuela, Cristina Benavides-Reyes, Luigi Nibali, Mark Ide, Giuseppe Mainas, Manfredi Rizzo, Antonio Magan-Fernandex^*

^*Corresponding author for this work

Centre for Host Microbiome Interactions

University of Granada
Gastroenterology Service, Virgen de la Arrixaca University Hospital, 30120 Murcia
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, School of Medicine, University of Palermo

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of the most frequent tumours diagnosed and whose incidence increases every year. We describe, from its recent origin, the relationship between this bacterium and this type of cancer and the knowledge and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the main questions and further research perspectives are presented

Original language	English
Article number	546
Pages (from-to)	546
Journal	Medicina
Volume	58
Issue number	4
DOIs	https://doi.org/10.3390/medicina58040546
Publication status	Published - 15 Apr 2022

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title = "A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer",

abstract = "There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of the most frequent tumours diagnosed and whose incidence increases every year. We describe, from its recent origin, the relationship between this bacterium and this type of cancer and the knowledge and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the main questions and further research perspectives are presented",

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AU - Mesa, Francesco

AU - Mesa-Lopez, Maria Jose

AU - Egea-Valenzuela, Juan

AU - Benavides-Reyes, Cristina

AU - Nibali, Luigi

AU - Ide, Mark

AU - Mainas, Giuseppe

AU - Rizzo, Manfredi

AU - Magan-Fernandex, Antonio

PY - 2022/4/15

Y1 - 2022/4/15

N2 - There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of the most frequent tumours diagnosed and whose incidence increases every year. We describe, from its recent origin, the relationship between this bacterium and this type of cancer and the knowledge and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the main questions and further research perspectives are presented

AB - There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of the most frequent tumours diagnosed and whose incidence increases every year. We describe, from its recent origin, the relationship between this bacterium and this type of cancer and the knowledge and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the main questions and further research perspectives are presented

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A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer

Abstract

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