Abstract
A concise synthesis of three novel C2–C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepine analogues (18–20) containing conjugated acrylyl C2-substituents is reported that utilises Heck coupling to install the C2-acrylyl side chains. These analogues possess significant cytotoxicity according to the NCI 60-cell line screen with 18 surpassing anthramycin (1) in potency.
Original language | English |
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Pages (from-to) | 1547-1549 |
Number of pages | 3 |
Journal | Bioorganic & medicinal chemistry letters |
Volume | 14 |
Issue number | 6 |
DOIs | |
Publication status | Published - 22 Mar 2004 |