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A polygenic score for age-at-first-birth predicts disinhibition

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A polygenic score for age-at-first-birth predicts disinhibition. / Richmond-Rakerd, Leah S.; Moffitt, Terrie Edith; Arseneault, Louise; Belsky, Daniel W.; Connor, Jennie; Corcoran, David L.; Harrington, HonaLee; Houts, Renate; Poulton, Richie; Prinz, Joey; Ramrakha, Sandhya; Sugden, Karen; Wertz, Jasmin; Williams, Benjamin; Caspi, Avshalom.

In: Journal of child psychology and psychiatry, 03.02.2020.

Research output: Contribution to journalArticle

Harvard

Richmond-Rakerd, LS, Moffitt, TE, Arseneault, L, Belsky, DW, Connor, J, Corcoran, DL, Harrington, H, Houts, R, Poulton, R, Prinz, J, Ramrakha, S, Sugden, K, Wertz, J, Williams, B & Caspi, A 2020, 'A polygenic score for age-at-first-birth predicts disinhibition', Journal of child psychology and psychiatry.

APA

Richmond-Rakerd, L. S., Moffitt, T. E., Arseneault, L., Belsky, D. W., Connor, J., Corcoran, D. L., Harrington, H., Houts, R., Poulton, R., Prinz, J., Ramrakha, S., Sugden, K., Wertz, J., Williams, B., & Caspi, A. (Accepted/In press). A polygenic score for age-at-first-birth predicts disinhibition. Journal of child psychology and psychiatry.

Vancouver

Richmond-Rakerd LS, Moffitt TE, Arseneault L, Belsky DW, Connor J, Corcoran DL et al. A polygenic score for age-at-first-birth predicts disinhibition. Journal of child psychology and psychiatry. 2020 Feb 3.

Author

Richmond-Rakerd, Leah S. ; Moffitt, Terrie Edith ; Arseneault, Louise ; Belsky, Daniel W. ; Connor, Jennie ; Corcoran, David L. ; Harrington, HonaLee ; Houts, Renate ; Poulton, Richie ; Prinz, Joey ; Ramrakha, Sandhya ; Sugden, Karen ; Wertz, Jasmin ; Williams, Benjamin ; Caspi, Avshalom. / A polygenic score for age-at-first-birth predicts disinhibition. In: Journal of child psychology and psychiatry. 2020.

Bibtex Download

@article{198cbc87dd014651a112600d90972e2b,
title = "A polygenic score for age-at-first-birth predicts disinhibition",
abstract = "Background. A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.Methods. We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N=1,999) and the four-decade-long Dunedin Study (N=918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life-course, including low childhood self-control; risk for externalizing psychopathology; officially-recorded criminal offending; substance-dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. Results. In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially-recorded criminal offending, substance-dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In constrast, associations were not attributable to accelerated pubertal timing.Conclusions. Genomic discoveries for age-at-first-birth are about more than reproductive biology: they provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.",
keywords = "Reproductive behavior, risk-taking, genetics, self-control, longitudinal",
author = "Richmond-Rakerd, {Leah S.} and Moffitt, {Terrie Edith} and Louise Arseneault and Belsky, {Daniel W.} and Jennie Connor and Corcoran, {David L.} and HonaLee Harrington and Renate Houts and Richie Poulton and Joey Prinz and Sandhya Ramrakha and Karen Sugden and Jasmin Wertz and Benjamin Williams and Avshalom Caspi",
year = "2020",
month = feb,
day = "3",
language = "English",
journal = "Journal of child psychology and psychiatry",
issn = "0021-9630",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A polygenic score for age-at-first-birth predicts disinhibition

AU - Richmond-Rakerd, Leah S.

AU - Moffitt, Terrie Edith

AU - Arseneault, Louise

AU - Belsky, Daniel W.

AU - Connor, Jennie

AU - Corcoran, David L.

AU - Harrington, HonaLee

AU - Houts, Renate

AU - Poulton, Richie

AU - Prinz, Joey

AU - Ramrakha, Sandhya

AU - Sugden, Karen

AU - Wertz, Jasmin

AU - Williams, Benjamin

AU - Caspi, Avshalom

PY - 2020/2/3

Y1 - 2020/2/3

N2 - Background. A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.Methods. We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N=1,999) and the four-decade-long Dunedin Study (N=918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life-course, including low childhood self-control; risk for externalizing psychopathology; officially-recorded criminal offending; substance-dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. Results. In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially-recorded criminal offending, substance-dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In constrast, associations were not attributable to accelerated pubertal timing.Conclusions. Genomic discoveries for age-at-first-birth are about more than reproductive biology: they provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.

AB - Background. A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.Methods. We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N=1,999) and the four-decade-long Dunedin Study (N=918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life-course, including low childhood self-control; risk for externalizing psychopathology; officially-recorded criminal offending; substance-dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. Results. In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially-recorded criminal offending, substance-dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In constrast, associations were not attributable to accelerated pubertal timing.Conclusions. Genomic discoveries for age-at-first-birth are about more than reproductive biology: they provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.

KW - Reproductive behavior

KW - risk-taking

KW - genetics

KW - self-control

KW - longitudinal

M3 - Article

JO - Journal of child psychology and psychiatry

JF - Journal of child psychology and psychiatry

SN - 0021-9630

ER -

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