A population-based comparison of the survival of patients with colorectal cancer in England, Norway and Sweden between 1996 and 2004

Eva J. A. Morris, Fredrik Sandin, Paul C. Lambert, Freddie Bray, Asa Klint, Karen Linklater, David Robinson, Lars Pahlman, Lars Holmberg, Henrik Moller

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    74 Citations (Scopus)

    Abstract

    Objective
    To examine differences in the relative survival and excess death rates of patients with colorectal cancer in Norway, Sweden and England.

    Methods
    All individuals diagnosed with colorectal cancer (ICD10 (International Classification of Diseases, 10th revision) C18-C20) between 1996 and 2004 in England, Norway and Sweden were included in this population-based study of patients with colorectal cancer. The main outcome measures were 5-year cumulative relative period of survival and excess death rates stratified by age and period of follow-up.

    Results
    The survival of English patients with colorectal cancer was significantly lower than was observed in both Norway and Sweden. Five-year age-standardised colon cancer relative survival was 51.1% (95% CI 50.1% to 52.0%) in England compared with 57.9% (95% CI 55.2% to 60.5%) in Norway and 59.9% (95% CI 57.7% to 62.0%) in Sweden. Five-year rectal cancer survival was 52.3% (95% CI 51.1% to 53.5%) in England compared with 60.7% (95% CI 57.0% to 64.2%) and 59.8% (95% CI 56.9% to 62.6%) in Norway and Sweden, respectively. The lower survival for colon cancer in England was primarily due to a high number of excess deaths among older patients in the first 3 months after diagnosis. In patients with rectal cancer, excess deaths remained elevated until 2 years of follow-up. If the lower excess death rate in Norway applied in the English population, then 890 (13.6%) and 654 (16.8%) of the excess deaths in the colon and rectal cancer populations, respectively, could have been prevented at 5 years follow-up. Most of these avoidable deaths occurred shortly after diagnosis.

    Conclusions
    There was significant variation in survival between the countries, with the English population experiencing a poorer outcome, primarily due to a relatively higher number of excess deaths in older patients in the short term after diagnosis. It seems likely, therefore, that in England a greater proportion of the population present with more rapidly fatal disease (especially in the older age groups) than in Norway or Sweden.
    Original languageEnglish
    Pages (from-to)1087-1093
    Number of pages7
    JournalGut
    Volume60
    Issue number8
    DOIs
    Publication statusPublished - Aug 2011

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