A practical guide to thiopurine prescribing and monitoring in IBD

Ben Warner*, Emma Johnston, Monica Arenas-HernandeZ, Anthony Marinaki, Peter Irving, Jeremy Sanderson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)


Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalFrontline Gastroenterology
Issue number1
Early online date29 Aug 2016
Publication statusPublished - 2018

Cite this