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A practical guide to thiopurine prescribing and monitoring in IBD

Research output: Contribution to journalReview articlepeer-review

Ben Warner, Emma Johnston, Monica Arenas-HernandeZ, Anthony Marinaki, Peter Irving, Jeremy Sanderson

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalFrontline Gastroenterology
Volume9
Issue number1
Early online date29 Aug 2016
DOIs
Accepted/In press8 Aug 2016
E-pub ahead of print29 Aug 2016
Published2018

King's Authors

Abstract

Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.

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