A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Marta Di Forti; Benjamin W. Bond; Edoardo Spinazzola; Giulia Trotta; Jodie Lynn; Richard Malkin; Naba Kamran Siddiqui; Sultan Demir; Titilayomi Opadokun; Perry B.M. Leung; Zhikun Li; Andrea Quattrone; Gabriella Baxter; Elizabeth Appiah-Kusi; Tom P. Freeman; Hannah Walsh; Tommaso Squeri; Daria Semikina; Felicity Amberson-Jones; Isabelle Austin-Zimmerman; Tim Meynen; Diego Quattrone; Robin M. Murray

doi:10.1192/bjo.2024.782

A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Marta Di Forti, Benjamin W. Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B.M. Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P. Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-ZimmermanTim Meynen, Diego Quattrone, Robin M. Murray

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.
Aims: Examine outcome data from the first 46 individuals to complete the CCP's intervention.MethodThe sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.
Results: A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.ConclusionsThe CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

Original language	English
Journal	BJPsych Open
Volume	11
Issue number	1
DOIs	https://doi.org/10.1192/bjo.2024.782
Publication status	Published - 12 Dec 2024

Keywords

Cannabis use
cessation
personalised
psychosis
psychosocial interventions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1192/bjo.2024.782

https://www.cambridge.org/core/product/230A8A7BCD3F53D64241DBEB00C74BE2

Cite this

Di Forti, M., Bond, B. W., Spinazzola, E., Trotta, G., Lynn, J., Malkin, R., Kamran Siddiqui, N., Demir, S., Opadokun, T., Leung, P. B. M., Li, Z., Quattrone, A., Baxter, G., Appiah-Kusi, E., Freeman, T. P., Walsh, H., Squeri, T., Semikina, D., Amberson-Jones, F., ... Murray, R. M. (2024). A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders. BJPsych Open, 11(1). https://doi.org/10.1192/bjo.2024.782

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title = "A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders",

abstract = "Background: Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.Aims: Examine outcome data from the first 46 individuals to complete the CCP's intervention.MethodThe sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.Results: A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.ConclusionsThe CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.",

keywords = "Cannabis use, cessation, personalised, psychosis, psychosocial interventions",

author = "{Di Forti}, Marta and Bond, {Benjamin W.} and Edoardo Spinazzola and Giulia Trotta and Jodie Lynn and Richard Malkin and {Kamran Siddiqui}, Naba and Sultan Demir and Titilayomi Opadokun and Leung, {Perry B.M.} and Zhikun Li and Andrea Quattrone and Gabriella Baxter and Elizabeth Appiah-Kusi and Freeman, {Tom P.} and Hannah Walsh and Tommaso Squeri and Daria Semikina and Felicity Amberson-Jones and Isabelle Austin-Zimmerman and Tim Meynen and Diego Quattrone and Murray, {Robin M.}",

year = "2024",

month = dec,

day = "12",

doi = "10.1192/bjo.2024.782",

language = "English",

volume = "11",

journal = "BJPsych Open",

issn = "2056-4724",

publisher = "Cambridge University Press",

number = "1",

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Di Forti, M, Bond, BW, Spinazzola, E , Trotta, G, Lynn, J, Malkin, R, Kamran Siddiqui, N, Demir, S, Opadokun, T, Leung, PBM , Li, Z, Quattrone, A, Baxter, G, Appiah-Kusi, E , Freeman, TP , Walsh, H, Squeri, T, Semikina, D, Amberson-Jones, F, Austin-Zimmerman, I , Meynen, T , Quattrone, D & Murray, RM 2024, 'A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders', BJPsych Open, vol. 11, no. 1. https://doi.org/10.1192/bjo.2024.782

TY - JOUR

T1 - A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

AU - Di Forti, Marta

AU - Bond, Benjamin W.

AU - Spinazzola, Edoardo

AU - Trotta, Giulia

AU - Lynn, Jodie

AU - Malkin, Richard

AU - Kamran Siddiqui, Naba

AU - Demir, Sultan

AU - Opadokun, Titilayomi

AU - Leung, Perry B.M.

AU - Li, Zhikun

AU - Quattrone, Andrea

AU - Baxter, Gabriella

AU - Appiah-Kusi, Elizabeth

AU - Freeman, Tom P.

AU - Walsh, Hannah

AU - Squeri, Tommaso

AU - Semikina, Daria

AU - Amberson-Jones, Felicity

AU - Austin-Zimmerman, Isabelle

AU - Meynen, Tim

AU - Quattrone, Diego

AU - Murray, Robin M.

PY - 2024/12/12

Y1 - 2024/12/12

N2 - Background: Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.Aims: Examine outcome data from the first 46 individuals to complete the CCP's intervention.MethodThe sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.Results: A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.ConclusionsThe CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

AB - Background: Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.Aims: Examine outcome data from the first 46 individuals to complete the CCP's intervention.MethodThe sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.Results: A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.ConclusionsThe CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

KW - Cannabis use

KW - cessation

KW - personalised

KW - psychosis

KW - psychosocial interventions

U2 - 10.1192/bjo.2024.782

DO - 10.1192/bjo.2024.782

M3 - Article

SN - 2056-4724

VL - 11

JO - BJPsych Open

JF - BJPsych Open

IS - 1

ER -

A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Abstract

Keywords

UN SDGs

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