A prospective study of chemotherapy-induced febrile neutropenia in the South West London Cancer Network. Interpretation of study results in light of NCAG/NCEPOD findings

M. Okera, S. Chan, U. Dernede, J. Larkin, S. Popat, D. Gilbert, L. Jones, N. Osuji, H. Sykes, C. Oakley, L. Pickering, F. Lofts, S. Chowdhury*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    BACKGROUND: Chemotherapy-induced febrile neutropenia is a medical emergency complicating the treatment of many cancer patients. It is associated with considerable morbidity and mortality, as well as impacting on healthcare resources.

    METHODS: A prospective study of all cases of chemotherapy-induced febrile neutropenia in the South West London Cancer Network was conducted over a 4-month period. Factors including demographics, treatment history, management of febrile neutropenia and outcome were recorded.

    RESULTS AND CONCLUSION: Our results reflect those of the recent National Chemotherapy Advisory Group (NCEPOD, 2008)/National Confidential Enquiry into Patient Outcomes and Death reports (NCAG, 2009) and highlight the need for network-wide c inical care pathways to improve outcomes in this area.

    Original languageEnglish
    Pages (from-to)407-412
    Number of pages6
    JournalBJC: British Journal of Cancer
    Volume104
    Issue number3
    DOIs
    Publication statusPublished - 1 Feb 2011

    Keywords

    • neutropenic sepsis
    • chemotherapy
    • infection
    • febrile neutropenia
    • COLONY-STIMULATING FACTORS
    • NON-HODGKINS-LYMPHOMA
    • RANDOMIZED CONTROLLED-TRIAL
    • ANTIBACTERIAL PROPHYLAXIS
    • ELDERLY-PATIENTS
    • DOSE-INTENSITY
    • SOLID TUMORS
    • MORTALITY
    • METAANALYSIS
    • GUIDELINES

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