A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance

O D Howes, A Bhatnagar, F P Gaughran, S A Amiel, R M Murray, L S Pilowsky

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74 Citations (Scopus)

Abstract

Objective: This prospective study examines the effect of clozapine on glucose control and insulin sensitivity. Method: Glucose homeostasis was measured in nine female and 11 male patients with schizophrenia (mean age = 30.5 years, SD = 7.4) before clozapine treatment and after a mean of 2.5 months (SD = 0.95) of clozapine treatment. Oral glucose tolerance and insulin levels were measured. insulin resistance level was measured by the homeostasis model assessment. Results: Eleven (55%) of the patients developed abnormal glucose control; the mean age of these patients was 30.2 (SD = 7.1), and five were women. Patients' insulin resistance at baseline (mean insulin resistance level = -3.88, SD = 2.93) was unaffected by clozapine. Mean fasting and 2-hour glucose levels significantly increased by 0.55 mmol/liter and 1.4 mmol/liter, respectively. There was no correlation between change in body mass index and change in fasting glucose levels. Conclusions: Clozapine impairs glucose control within 4 months of treatment, independent of changes in insulin sensitivity and body mass index.
Original languageEnglish
Pages (from-to)361 - 363
Number of pages3
JournalThe American Journal of Psychiatry
Volume161
Issue number2
DOIs
Publication statusPublished - Feb 2004

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