A prospective study of quality of life in ALS patients treated with noninvasive ventilation

R A Lyall; N Donaldson; T Fleming; C Wood; I Newsom-Davis; M I Polkey; P N Leigh; J Moxham

A prospective study of quality of life in ALS patients treated with noninvasive ventilation

R A Lyall, N Donaldson, T Fleming, C Wood, I Newsom-Davis, M I Polkey, P N Leigh, J Moxham

King's College London

Research output: Contribution to journal › Article › peer-review

228 Citations (Scopus)

Abstract

Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.

Original language	English
Pages (from-to)	153 - 156
Number of pages	4
Journal	Neurology
Volume	57
Issue number	1
Publication status	Published - 10 Jul 2001

Cite this

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AU - Lyall, R A

AU - Donaldson, N

AU - Fleming, T

AU - Wood, C

AU - Newsom-Davis, I

AU - Polkey, M I

AU - Leigh, P N

AU - Moxham, J

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N2 - Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.

AB - Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.

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JO - Neurology

JF - Neurology

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A prospective study of quality of life in ALS patients treated with noninvasive ventilation

Abstract

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