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A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations

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A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations. / Strocchi, Marina; Augustin, Christoph M.; Gsell, Matthias A.F.; Karabelas, Elias; Neic, Aurel; Gillette, Karli; Razeghi, Orod; Prassl, Anton J.; Vigmond, Edward J.; Vigmond, Edward J.; Behar, Jonathan M.; Behar, Jonathan M.; Gould, Justin; Gould, Justin; Sidhu, Baldeep; Sidhu, Baldeep; Rinaldi, Christopher A.; Rinaldi, Christopher A.; Bishop, Martin J.; Plank, Gernot; Niederer, Steven A.

In: PLoS ONE, Vol. 15, No. 6 June, e0235145, 06.2020.

Research output: Contribution to journalArticle

Harvard

Strocchi, M, Augustin, CM, Gsell, MAF, Karabelas, E, Neic, A, Gillette, K, Razeghi, O, Prassl, AJ, Vigmond, EJ, Vigmond, EJ, Behar, JM, Behar, JM, Gould, J, Gould, J, Sidhu, B, Sidhu, B, Rinaldi, CA, Rinaldi, CA, Bishop, MJ, Plank, G & Niederer, SA 2020, 'A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations', PLoS ONE, vol. 15, no. 6 June, e0235145. https://doi.org/10.1371/journal.pone.0235145

APA

Strocchi, M., Augustin, C. M., Gsell, M. A. F., Karabelas, E., Neic, A., Gillette, K., Razeghi, O., Prassl, A. J., Vigmond, E. J., Vigmond, E. J., Behar, J. M., Behar, J. M., Gould, J., Gould, J., Sidhu, B., Sidhu, B., Rinaldi, C. A., Rinaldi, C. A., Bishop, M. J., ... Niederer, S. A. (2020). A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations. PLoS ONE, 15(6 June), [e0235145]. https://doi.org/10.1371/journal.pone.0235145

Vancouver

Strocchi M, Augustin CM, Gsell MAF, Karabelas E, Neic A, Gillette K et al. A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations. PLoS ONE. 2020 Jun;15(6 June). e0235145. https://doi.org/10.1371/journal.pone.0235145

Author

Strocchi, Marina ; Augustin, Christoph M. ; Gsell, Matthias A.F. ; Karabelas, Elias ; Neic, Aurel ; Gillette, Karli ; Razeghi, Orod ; Prassl, Anton J. ; Vigmond, Edward J. ; Vigmond, Edward J. ; Behar, Jonathan M. ; Behar, Jonathan M. ; Gould, Justin ; Gould, Justin ; Sidhu, Baldeep ; Sidhu, Baldeep ; Rinaldi, Christopher A. ; Rinaldi, Christopher A. ; Bishop, Martin J. ; Plank, Gernot ; Niederer, Steven A. / A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations. In: PLoS ONE. 2020 ; Vol. 15, No. 6 June.

Bibtex Download

@article{8e89c4c2261b4d24b69a970fbe326399,
title = "A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations",
abstract = "Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. To facilitate the development of new simulation and model analysis techniques by groups without direct access to medical data, image analysis techniques and meshing tools, we have created the first publicly available virtual cohort of twenty-four four-chamber hearts. Our cohort was built from heart failure patients, age 67±14 years. We segmented four-chamber heart geometries from end-diastolic (ED) CT images and generated linear tetrahedral meshes with an average edge length of 1.1 ±0.2mm. Ventricular fibres were added in the ventricles with a rule-based method with an orientation of -60° and 80° at the epicardium and endocardium, respectively. We additionally refined the meshes to an average edge length of 0.39±0.10mm to show that all given meshes can be resampled to achieve an arbitrary desired resolution. We ran simulations for ventricular electrical activation and free mechanical contraction on all 1.1mm-resolution meshes to ensure that our meshes are suitable for electro-mechanical simulations. Simulations for electrical activation resulted in a total activation time of 149±16ms. Free mechanical contractions gave an average left ventricular (LV) and right ventricular (RV) ejection fraction (EF) of 35±1% and 30±2%, respectively, and a LV and RV stroke volume (SV) of 95±28mL and 65±11mL, respectively. By making the cohort publicly available, we hope to facilitate large cohort computational studies and to promote the development of cardiac computational electro-mechanics for clinical applications.",
author = "Marina Strocchi and Augustin, {Christoph M.} and Gsell, {Matthias A.F.} and Elias Karabelas and Aurel Neic and Karli Gillette and Orod Razeghi and Prassl, {Anton J.} and Vigmond, {Edward J.} and Vigmond, {Edward J.} and Behar, {Jonathan M.} and Behar, {Jonathan M.} and Justin Gould and Justin Gould and Baldeep Sidhu and Baldeep Sidhu and Rinaldi, {Christopher A.} and Rinaldi, {Christopher A.} and Bishop, {Martin J.} and Gernot Plank and Niederer, {Steven A.}",
year = "2020",
month = jun,
doi = "10.1371/journal.pone.0235145",
language = "English",
volume = "15",
journal = "PL o S One ",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6 June",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A publicly available virtual cohort of fourchamber heart meshes for cardiac electromechanics simulations

AU - Strocchi, Marina

AU - Augustin, Christoph M.

AU - Gsell, Matthias A.F.

AU - Karabelas, Elias

AU - Neic, Aurel

AU - Gillette, Karli

AU - Razeghi, Orod

AU - Prassl, Anton J.

AU - Vigmond, Edward J.

AU - Vigmond, Edward J.

AU - Behar, Jonathan M.

AU - Behar, Jonathan M.

AU - Gould, Justin

AU - Gould, Justin

AU - Sidhu, Baldeep

AU - Sidhu, Baldeep

AU - Rinaldi, Christopher A.

AU - Rinaldi, Christopher A.

AU - Bishop, Martin J.

AU - Plank, Gernot

AU - Niederer, Steven A.

PY - 2020/6

Y1 - 2020/6

N2 - Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. To facilitate the development of new simulation and model analysis techniques by groups without direct access to medical data, image analysis techniques and meshing tools, we have created the first publicly available virtual cohort of twenty-four four-chamber hearts. Our cohort was built from heart failure patients, age 67±14 years. We segmented four-chamber heart geometries from end-diastolic (ED) CT images and generated linear tetrahedral meshes with an average edge length of 1.1 ±0.2mm. Ventricular fibres were added in the ventricles with a rule-based method with an orientation of -60° and 80° at the epicardium and endocardium, respectively. We additionally refined the meshes to an average edge length of 0.39±0.10mm to show that all given meshes can be resampled to achieve an arbitrary desired resolution. We ran simulations for ventricular electrical activation and free mechanical contraction on all 1.1mm-resolution meshes to ensure that our meshes are suitable for electro-mechanical simulations. Simulations for electrical activation resulted in a total activation time of 149±16ms. Free mechanical contractions gave an average left ventricular (LV) and right ventricular (RV) ejection fraction (EF) of 35±1% and 30±2%, respectively, and a LV and RV stroke volume (SV) of 95±28mL and 65±11mL, respectively. By making the cohort publicly available, we hope to facilitate large cohort computational studies and to promote the development of cardiac computational electro-mechanics for clinical applications.

AB - Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. To facilitate the development of new simulation and model analysis techniques by groups without direct access to medical data, image analysis techniques and meshing tools, we have created the first publicly available virtual cohort of twenty-four four-chamber hearts. Our cohort was built from heart failure patients, age 67±14 years. We segmented four-chamber heart geometries from end-diastolic (ED) CT images and generated linear tetrahedral meshes with an average edge length of 1.1 ±0.2mm. Ventricular fibres were added in the ventricles with a rule-based method with an orientation of -60° and 80° at the epicardium and endocardium, respectively. We additionally refined the meshes to an average edge length of 0.39±0.10mm to show that all given meshes can be resampled to achieve an arbitrary desired resolution. We ran simulations for ventricular electrical activation and free mechanical contraction on all 1.1mm-resolution meshes to ensure that our meshes are suitable for electro-mechanical simulations. Simulations for electrical activation resulted in a total activation time of 149±16ms. Free mechanical contractions gave an average left ventricular (LV) and right ventricular (RV) ejection fraction (EF) of 35±1% and 30±2%, respectively, and a LV and RV stroke volume (SV) of 95±28mL and 65±11mL, respectively. By making the cohort publicly available, we hope to facilitate large cohort computational studies and to promote the development of cardiac computational electro-mechanics for clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=85087321059&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0235145

DO - 10.1371/journal.pone.0235145

M3 - Article

C2 - 32589679

AN - SCOPUS:85087321059

VL - 15

JO - PL o S One

JF - PL o S One

SN - 1932-6203

IS - 6 June

M1 - e0235145

ER -

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