A Quantitative Analysis of Ureaplasma urealyticum and Ureaplasma parvum Compared with Host Immune Response in Preterm Neonates at Risk of Developing Bronchopulmonary Dysplasia

Matthew S. Payne, Kevin C. W. Goss, Gary J. Connett, Julian P. Legg, Ken D. Bruce, Vicki Chalker

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Multiplex, real-time PCR for the identification of Ureaplasma urealyticum and Ureaplasma parvum was performed on nucleic acids extracted from sequential endotracheal aspirates obtained from preterm neonates born at 10 mg/liter). This study was limited by the small number of patients examined and does not have the power to support or contradict the hypothesis that postnatal lung infection with Ureaplasma parvum is causally related to bronchopulmonary dysplasia (BPD) or adverse respiratory outcomes after preterm birth. However, in this study, increases in CRP levels were not associated with patients in whom Ureaplasma parvum was detected, in contrast to the detection of other bacterial species.
Original languageEnglish
Pages (from-to)909 - 914
Number of pages6
JournalJournal of Clinical Microbiology
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 2012

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