A randomised crossover trial of closed loop automated oxygen control in preterm, ventilated infants. Neonatal closed loop automated oxygen control

TY - JOUR

T1 - A randomised crossover trial of closed loop automated oxygen control in preterm, ventilated infants.

T2 - Neonatal closed loop automated oxygen control

AU - Sturrock, Sarah

AU - Ambulkar, Hemant

AU - Williams, Emma

AU - Sweeney, Samantha

AU - Bednarczuk, Nadja

AU - Dassios, Theodore

AU - Greenough, Anne

PY - 2020

Y1 - 2020

N2 - Aim: To determine whether closed loop automated oxygen control resulted in a reduction in the duration and severity of desaturation episodes and the number of blood gases and chest radiographs in preterm, ventilated infants. Methods: Infants were studied on two consecutive days for 12 hours on each day. They were randomised to receive standard care (standard period) or standard care with a closed loop automated oxygen control system (automated oxygen control period) first. Results: Twenty-four infants with a median gestational age of 25.7 (range 23.1-32.6) weeks were studied at a median postconceptional age of 27.4 (range 24.3-34.9) weeks. During the automated oxygen control period, there were fewer desaturations that lasted >30 seconds (P =.032) or >60 seconds (P =.002), infants spent a higher proportion of the time within their target SpO 2 range during the automated oxygen control period (P <.001), and fewer manual adjustments were made to the inspired oxygen concentration (mean 0.58 vs mean 11.29) (P <.001). There were no significant differences in the number of blood gases (P =.872) or chest radiographs (P =.366) between the two periods. Conclusion: Closed loop automated oxygen delivery resulted in fewer prolonged desaturations with more time spent in the targeted oxygen range.

AB - Aim: To determine whether closed loop automated oxygen control resulted in a reduction in the duration and severity of desaturation episodes and the number of blood gases and chest radiographs in preterm, ventilated infants. Methods: Infants were studied on two consecutive days for 12 hours on each day. They were randomised to receive standard care (standard period) or standard care with a closed loop automated oxygen control system (automated oxygen control period) first. Results: Twenty-four infants with a median gestational age of 25.7 (range 23.1-32.6) weeks were studied at a median postconceptional age of 27.4 (range 24.3-34.9) weeks. During the automated oxygen control period, there were fewer desaturations that lasted >30 seconds (P =.032) or >60 seconds (P =.002), infants spent a higher proportion of the time within their target SpO 2 range during the automated oxygen control period (P <.001), and fewer manual adjustments were made to the inspired oxygen concentration (mean 0.58 vs mean 11.29) (P <.001). There were no significant differences in the number of blood gases (P =.872) or chest radiographs (P =.366) between the two periods. Conclusion: Closed loop automated oxygen delivery resulted in fewer prolonged desaturations with more time spent in the targeted oxygen range.

KW - closed loop automated oxygen delivery

KW - desaturation

KW - hyperoxia

UR - http://www.scopus.com/inward/record.url?scp=85092098067&partnerID=8YFLogxK

U2 - 10.1111/apa.15585

DO - 10.1111/apa.15585

M3 - Article

SN - 0803-5253

JO - Acta Paediatrica

JF - Acta Paediatrica

ER -