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A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial

Research output: Contribution to journalArticle

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A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial. / Patterson, Tiffany; Perkins, Gavin D.; Joseph, Jubin; Wilson, Karen; Van Dyck, Laura; Roberston, Steven; Nguyen, Hanna; McConkey, Hannah; Whitbread, Mark; Fothergill, Rachael; Nevett, Joanne; Dalby, Miles; Rakhit, Roby; MacCarthy, Philip; Perera, Divaka; Nolan, Jerry P.; Redwood, Simon R.

In: Resuscitation, Vol. 115, 06.2017, p. 185-191.

Research output: Contribution to journalArticle

Harvard

Patterson, T, Perkins, GD, Joseph, J, Wilson, K, Van Dyck, L, Roberston, S, Nguyen, H, McConkey, H, Whitbread, M, Fothergill, R, Nevett, J, Dalby, M, Rakhit, R, MacCarthy, P, Perera, D, Nolan, JP & Redwood, SR 2017, 'A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial', Resuscitation, vol. 115, pp. 185-191. https://doi.org/10.1016/j.resuscitation.2017.01.020

APA

Patterson, T., Perkins, G. D., Joseph, J., Wilson, K., Van Dyck, L., Roberston, S., ... Redwood, S. R. (2017). A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial. Resuscitation, 115, 185-191. https://doi.org/10.1016/j.resuscitation.2017.01.020

Vancouver

Patterson T, Perkins GD, Joseph J, Wilson K, Van Dyck L, Roberston S et al. A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial. Resuscitation. 2017 Jun;115:185-191. https://doi.org/10.1016/j.resuscitation.2017.01.020

Author

Patterson, Tiffany ; Perkins, Gavin D. ; Joseph, Jubin ; Wilson, Karen ; Van Dyck, Laura ; Roberston, Steven ; Nguyen, Hanna ; McConkey, Hannah ; Whitbread, Mark ; Fothergill, Rachael ; Nevett, Joanne ; Dalby, Miles ; Rakhit, Roby ; MacCarthy, Philip ; Perera, Divaka ; Nolan, Jerry P. ; Redwood, Simon R. / A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial. In: Resuscitation. 2017 ; Vol. 115. pp. 185-191.

Bibtex Download

@article{42abbdc71c7e46679f0dab1751cf4456,
title = "A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial",
abstract = "Background Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC)may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation.The objective was to assess the feasibility of performing a large-scale randomised controlled trial. Methods Adult witnessed ventricular fibrillation OHCA of presumed cardiac cause were randomised 1:1 to either: 1) treatment: comprising expedited transfer to a CAC for goal-directed therapy including access to immediate reperfusion, or 2) control: comprising current standard of care involving delivery to the geographically closest hospital. The feasibility of randomisation, protocol adherence and data collection of the primary (30-day all-cause mortality) and secondary (cerebral performance category (CPC)) and in-hospital major cardiovascular and cerebrovascular events (MACCE)) clinical outcome measures were assessed. Results Between November 2014 and April 2016, 118 cases were screened, of which 63 patients (53{\%}) met eligibility criteria and 40 of the 63 patients (63{\%}) were randomised. There were no protocol deviations in the treatment arm. Data collection of primary and secondary outcomes was achieved in 83{\%}. There was no difference in baseline characteristicsbetween the groups: 30-day mortality (Intervention 9/18, 50{\%} vs. Control 6/15, 40{\%}; P = 0.73), CPC 1/2 (Intervention: 9/18, 50{\%} vs. Control 7/14, 50{\%}; P > 0.99) or MACCE (Intervention: 9/18, 50{\%} vs. Control 6/15, 40{\%}; P = 0.73). Conclusions These findings support the feasibility and acceptability of conducting a large-scale randomised controlled trial of expedited transfer to CAC following OHCA to address a remaining uncertainty in post-arrest care.",
keywords = "Out-of-hospital Cardiac Arrest, Cardiac Resuscitation Centre, Coronary Angiography",
author = "Tiffany Patterson and Perkins, {Gavin D.} and Jubin Joseph and Karen Wilson and {Van Dyck}, Laura and Steven Roberston and Hanna Nguyen and Hannah McConkey and Mark Whitbread and Rachael Fothergill and Joanne Nevett and Miles Dalby and Roby Rakhit and Philip MacCarthy and Divaka Perera and Nolan, {Jerry P.} and Redwood, {Simon R.}",
year = "2017",
month = "6",
doi = "10.1016/j.resuscitation.2017.01.020",
language = "English",
volume = "115",
pages = "185--191",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial

AU - Patterson, Tiffany

AU - Perkins, Gavin D.

AU - Joseph, Jubin

AU - Wilson, Karen

AU - Van Dyck, Laura

AU - Roberston, Steven

AU - Nguyen, Hanna

AU - McConkey, Hannah

AU - Whitbread, Mark

AU - Fothergill, Rachael

AU - Nevett, Joanne

AU - Dalby, Miles

AU - Rakhit, Roby

AU - MacCarthy, Philip

AU - Perera, Divaka

AU - Nolan, Jerry P.

AU - Redwood, Simon R.

PY - 2017/6

Y1 - 2017/6

N2 - Background Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC)may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation.The objective was to assess the feasibility of performing a large-scale randomised controlled trial. Methods Adult witnessed ventricular fibrillation OHCA of presumed cardiac cause were randomised 1:1 to either: 1) treatment: comprising expedited transfer to a CAC for goal-directed therapy including access to immediate reperfusion, or 2) control: comprising current standard of care involving delivery to the geographically closest hospital. The feasibility of randomisation, protocol adherence and data collection of the primary (30-day all-cause mortality) and secondary (cerebral performance category (CPC)) and in-hospital major cardiovascular and cerebrovascular events (MACCE)) clinical outcome measures were assessed. Results Between November 2014 and April 2016, 118 cases were screened, of which 63 patients (53%) met eligibility criteria and 40 of the 63 patients (63%) were randomised. There were no protocol deviations in the treatment arm. Data collection of primary and secondary outcomes was achieved in 83%. There was no difference in baseline characteristicsbetween the groups: 30-day mortality (Intervention 9/18, 50% vs. Control 6/15, 40%; P = 0.73), CPC 1/2 (Intervention: 9/18, 50% vs. Control 7/14, 50%; P > 0.99) or MACCE (Intervention: 9/18, 50% vs. Control 6/15, 40%; P = 0.73). Conclusions These findings support the feasibility and acceptability of conducting a large-scale randomised controlled trial of expedited transfer to CAC following OHCA to address a remaining uncertainty in post-arrest care.

AB - Background Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC)may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation.The objective was to assess the feasibility of performing a large-scale randomised controlled trial. Methods Adult witnessed ventricular fibrillation OHCA of presumed cardiac cause were randomised 1:1 to either: 1) treatment: comprising expedited transfer to a CAC for goal-directed therapy including access to immediate reperfusion, or 2) control: comprising current standard of care involving delivery to the geographically closest hospital. The feasibility of randomisation, protocol adherence and data collection of the primary (30-day all-cause mortality) and secondary (cerebral performance category (CPC)) and in-hospital major cardiovascular and cerebrovascular events (MACCE)) clinical outcome measures were assessed. Results Between November 2014 and April 2016, 118 cases were screened, of which 63 patients (53%) met eligibility criteria and 40 of the 63 patients (63%) were randomised. There were no protocol deviations in the treatment arm. Data collection of primary and secondary outcomes was achieved in 83%. There was no difference in baseline characteristicsbetween the groups: 30-day mortality (Intervention 9/18, 50% vs. Control 6/15, 40%; P = 0.73), CPC 1/2 (Intervention: 9/18, 50% vs. Control 7/14, 50%; P > 0.99) or MACCE (Intervention: 9/18, 50% vs. Control 6/15, 40%; P = 0.73). Conclusions These findings support the feasibility and acceptability of conducting a large-scale randomised controlled trial of expedited transfer to CAC following OHCA to address a remaining uncertainty in post-arrest care.

KW - Out-of-hospital Cardiac Arrest

KW - Cardiac Resuscitation Centre

KW - Coronary Angiography

U2 - 10.1016/j.resuscitation.2017.01.020

DO - 10.1016/j.resuscitation.2017.01.020

M3 - Article

VL - 115

SP - 185

EP - 191

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -

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