A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

Chunxin Lu; Kristine Laws; Arvin Eskandari; Kogularamanan Suntharalingam

doi:10.1039/c7dt02789c

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

Chemistry

King's College London

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Abstract

Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cellsand cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevatingt he intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression

Original language	English
Pages (from-to)	12785-12789
Number of pages	5
Journal	Dalton Transactions
Volume	46
Issue number	38
Early online date	4 Sept 2017
DOIs	https://doi.org/10.1039/c7dt02789c
Publication status	Published - 14 Oct 2017

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SDG 3 Good Health and Well-being

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10.1039/c7dt02789c

A reactive oxygen species_LU_Acc3Sept2017Epub4Sept2017_GREEN AAMAccepted author manuscript, 1.19 MB

Cite this

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title = "A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster",

abstract = "Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cellsand cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevatingt he intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression",

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T1 - A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

AU - Lu, Chunxin

AU - Laws, Kristine

AU - Eskandari, Arvin

AU - Suntharalingam, Kogularamanan

PY - 2017/10/14

Y1 - 2017/10/14

N2 - Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cellsand cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevatingt he intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression

AB - Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cellsand cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevatingt he intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression

U2 - 10.1039/c7dt02789c

DO - 10.1039/c7dt02789c

M3 - Article

SN - 1477-9226

VL - 46

SP - 12785

EP - 12789

JO - Dalton Transactions

JF - Dalton Transactions

IS - 38

ER -

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

Abstract

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