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A review of the longevity of effect of Botulinum Toxin in wrinkle treatments

Research output: Contribution to journalArticle

G. Smith, A. Lax, S. B. Mehta

Original languageEnglish
Number of pages27
JournalBritish Dental Journal
Issue number4
Early online date23 Feb 2018
Publication statusE-pub ahead of print - 23 Feb 2018


King's Authors


Botulinum toxin is widely used in facial rhytide treatments. The duration of its effect’s influences treatment intervals, cost and convenience to the patient. These are key factors in successful aesthetic procedures. A review of the literature found that duration of effect was between 2 and 6 months, with most experiencing loss of maximal contraction for 3-4 months. Treatments may last between 3-4 months, and occasionally up to 6 months. No specific definition of effectiveness/ efficacy has been described and used to measure comparable end points. Additional research should help clarify the impact of brand, age, gender, ethnicity, repetition of treatment and zinc-phytase supplementation.

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