A revised nomenclature for the lemur family of protein kinases

Gábor M Mórotz; Neil A Bradbury; Oana Caluseriu; Shin-Ichi Hisanaga; Christopher C J Miller; Agnieszka Swiatecka-Urban; Heinz-Josef Lenz; Stephen J Moss; Georgios Giamas

doi:10.1038/s42003-023-05671-8

A revised nomenclature for the lemur family of protein kinases

Gábor M Mórotz
, Neil A Bradbury
, Oana Caluseriu
, Shin-Ichi Hisanaga
, Christopher C J Miller
, Agnieszka Swiatecka-Urban
, Heinz-Josef Lenz
, Stephen J Moss
, Georgios Giamas

Basic and Clinical Neuroscience

Semmelweis University
University of Chicago
University of Alberta Hospital
Tokyo Metropolitan University
Department of Basic and Clinical Neuroscience
Institute of Psychiatry
Psychology and Neuroscience
King's College London
University of Virginia
University of Southern California/Norris Comprehensive Cancer Centre
Tufts University
University of Sussex

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

74 Downloads (Pure)

Abstract

The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory and learning, and they are centrally placed in several intracellular signalling pathways. Numerous studies have also implicated role of the lemur kinases in the development and progression of a wide range of cancers, cystic fibrosis, and neurodegenerative diseases. However, parallel discoveries and inaccurate prediction of their kinase activity have resulted in a confusing and misleading nomenclature of these proteins. Herein, a group of international scientists with expertise in lemur family of protein kinases set forth a novel nomenclature to rectify this problem and ultimately help the scientific community by providing consistent information about these molecules.

Original language	English
Article number	57
Pages (from-to)	57
Journal	Communications Biology
Volume	7
Issue number	1
Early online date	8 Jan 2024
DOIs	https://doi.org/10.1038/s42003-023-05671-8
Publication status	E-pub ahead of print - 8 Jan 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Lemur
Protein Kinases
Phosphorylation
Axonal Transport
Cystic Fibrosis

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A revised nomenclature for_Morotz_publishedonline08January2024_Gold_VOR (CC BY)Final published version, 0.99 MBLicence: CC BY

Cite this

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abstract = "The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory and learning, and they are centrally placed in several intracellular signalling pathways. Numerous studies have also implicated role of the lemur kinases in the development and progression of a wide range of cancers, cystic fibrosis, and neurodegenerative diseases. However, parallel discoveries and inaccurate prediction of their kinase activity have resulted in a confusing and misleading nomenclature of these proteins. Herein, a group of international scientists with expertise in lemur family of protein kinases set forth a novel nomenclature to rectify this problem and ultimately help the scientific community by providing consistent information about these molecules.",

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AU - Mórotz, Gábor M

AU - Bradbury, Neil A

AU - Caluseriu, Oana

AU - Hisanaga, Shin-Ichi

AU - Miller, Christopher C J

AU - Swiatecka-Urban, Agnieszka

AU - Lenz, Heinz-Josef

AU - Moss, Stephen J

AU - Giamas, Georgios

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AB - The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory and learning, and they are centrally placed in several intracellular signalling pathways. Numerous studies have also implicated role of the lemur kinases in the development and progression of a wide range of cancers, cystic fibrosis, and neurodegenerative diseases. However, parallel discoveries and inaccurate prediction of their kinase activity have resulted in a confusing and misleading nomenclature of these proteins. Herein, a group of international scientists with expertise in lemur family of protein kinases set forth a novel nomenclature to rectify this problem and ultimately help the scientific community by providing consistent information about these molecules.

KW - Animals

KW - Lemur

KW - Protein Kinases

KW - Phosphorylation

KW - Axonal Transport

KW - Cystic Fibrosis

UR - https://www.scopus.com/pages/publications/85181907275

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ER -

A revised nomenclature for the lemur family of protein kinases

Abstract

UN SDGs

Keywords

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