A revised view of the role of CaMKII in learning and memory

K Ulli Bayer; Peter Giese

doi:10.1038/s41593-024-01809-x

A revised view of the role of CaMKII in learning and memory

K Ulli Bayer, Peter Giese

Basic and Clinical Neuroscience

University of Colorado

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The Ca2+/Calmodulin(CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at T286 (pT286) does not provide the molecular basis for long-term memory, as long believed. Instead, pT286 mediates the signal processing required for induction of several distinct forms of synaptic plasticity, including Hebbian long-term potentiation and depression (LTP and LTD) and non-Hebbian behavioral timescale synaptic plasticity (BTSP). We discuss (i) the molecular computations by which CaMKII supports these diverse plasticity mechanisms, (ii) alternative CaMKII mechanisms that may contribute to the maintenance phase of LTP, and (iii) the relationship of these mechanisms to behavioral learning and memory

Original language	English
Journal	Nature neuroscience
DOIs	https://doi.org/10.1038/s41593-024-01809-x
Publication status	Published - 18 Nov 2024

Keywords

Learning, memory, synapse, signalling

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title = "A revised view of the role of CaMKII in learning and memory",

abstract = "The Ca2+/Calmodulin(CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at T286 (pT286) does not provide the molecular basis for long-term memory, as long believed. Instead, pT286 mediates the signal processing required for induction of several distinct forms of synaptic plasticity, including Hebbian long-term potentiation and depression (LTP and LTD) and non-Hebbian behavioral timescale synaptic plasticity (BTSP). We discuss (i) the molecular computations by which CaMKII supports these diverse plasticity mechanisms, (ii) alternative CaMKII mechanisms that may contribute to the maintenance phase of LTP, and (iii) the relationship of these mechanisms to behavioral learning and memory",

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T1 - A revised view of the role of CaMKII in learning and memory

AU - Bayer, K Ulli

AU - Giese, Peter

PY - 2024/11/18

Y1 - 2024/11/18

N2 - The Ca2+/Calmodulin(CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at T286 (pT286) does not provide the molecular basis for long-term memory, as long believed. Instead, pT286 mediates the signal processing required for induction of several distinct forms of synaptic plasticity, including Hebbian long-term potentiation and depression (LTP and LTD) and non-Hebbian behavioral timescale synaptic plasticity (BTSP). We discuss (i) the molecular computations by which CaMKII supports these diverse plasticity mechanisms, (ii) alternative CaMKII mechanisms that may contribute to the maintenance phase of LTP, and (iii) the relationship of these mechanisms to behavioral learning and memory

AB - The Ca2+/Calmodulin(CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at T286 (pT286) does not provide the molecular basis for long-term memory, as long believed. Instead, pT286 mediates the signal processing required for induction of several distinct forms of synaptic plasticity, including Hebbian long-term potentiation and depression (LTP and LTD) and non-Hebbian behavioral timescale synaptic plasticity (BTSP). We discuss (i) the molecular computations by which CaMKII supports these diverse plasticity mechanisms, (ii) alternative CaMKII mechanisms that may contribute to the maintenance phase of LTP, and (iii) the relationship of these mechanisms to behavioral learning and memory

KW - Learning, memory, synapse, signalling

U2 - 10.1038/s41593-024-01809-x

DO - 10.1038/s41593-024-01809-x

M3 - Review article

SN - 1546-1726

JO - Nature neuroscience

JF - Nature neuroscience

ER -

A revised view of the role of CaMKII in learning and memory

Abstract

Keywords

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