A role for thalamic projection GABAergic neurons in circadian responses to light

Olivier Brock; Cigdem Gelegen; Peter Sully; Irene  Salgarella; Polona Jager; Lucy Menage; Ishita Mehta; Jagoda Jęczmień-Łazur; Deyl Djama; Lauren Strother; Angelica Coculla; Anthony Vernon; Stephen G. Brickley; Philip Holland; Samuel Cooke; Alessio Delogu

A role for thalamic projection GABAergic neurons in circadian responses to light

Olivier Brock, Cigdem Gelegen, Peter Sully, Irene Salgarella, Polona Jager, Lucy Menage, Ishita Mehta, Jagoda Jęczmień-Łazur, Deyl Djama, Lauren Strother, Angelica Coculla, Anthony Vernon, Stephen G. Brickley, Philip Holland, Samuel Cooke, Alessio Delogu

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Abstract

The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex. Here, we have harnessed recent insight into the development of the intergeniculate leaflet (IGL) and the ventral lateral geniculate nucleus (LGv) to specifically target and manipulate thalamic projection GABAergic neurons in female and male mice. Our results show that thalamic GABAergic neurons of the IGL and LGv receive retinal input from diverse classes of retinal ganglion cells (RGCs) but not from the M1 intrinsically photosensitive retinal ganglion cell (ipRGC) type. We describe the synergistic role of the photoreceptor melanopsin and the thalamic neurons of the IGL/LGv in circadian entrainment to dim light. We identify a requirement for the thalamic IGL/LGv neurons in the rapid changes in vigilance states associated with circadian light transitions.

Original language	English
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Publication status	Published - 7 Dec 2022

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Brock et al., Journal of Neuroscience 2022Final published version, 12.3 MBLicence: CC BY

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A role for thalamic projection GABAergic neurons in circadian responses to light
Brock, O., Gelegen, C. E., Salgarella, I., Sully, P., Jager, P., Menage, L., Mehta, I., Jk eczmień-Łazur, J., Djama, D., Strother, L., Coculla, A., Vernon, A., Brickley, S., Holland, P., Cooke, S. & Delogu, A., 2022, In: bioRxiv.
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Brock, O., Gelegen, C., Sully, P., Salgarella, I., Jager, P., Menage, L., Mehta, I., Jęczmień-Łazur, J., Djama, D., Strother, L., Coculla, A., Vernon, A., Brickley, S. G., Holland, P., Cooke, S., & Delogu, A. (2022). A role for thalamic projection GABAergic neurons in circadian responses to light. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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title = "A role for thalamic projection GABAergic neurons in circadian responses to light",

abstract = "The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex. Here, we have harnessed recent insight into the development of the intergeniculate leaflet (IGL) and the ventral lateral geniculate nucleus (LGv) to specifically target and manipulate thalamic projection GABAergic neurons in female and male mice. Our results show that thalamic GABAergic neurons of the IGL and LGv receive retinal input from diverse classes of retinal ganglion cells (RGCs) but not from the M1 intrinsically photosensitive retinal ganglion cell (ipRGC) type. We describe the synergistic role of the photoreceptor melanopsin and the thalamic neurons of the IGL/LGv in circadian entrainment to dim light. We identify a requirement for the thalamic IGL/LGv neurons in the rapid changes in vigilance states associated with circadian light transitions.",

author = "Olivier Brock and Cigdem Gelegen and Peter Sully and Irene Salgarella and Polona Jager and Lucy Menage and Ishita Mehta and Jagoda J{\c e}czmie{\'n}-{\L}azur and Deyl Djama and Lauren Strother and Angelica Coculla and Anthony Vernon and Brickley, {Stephen G.} and Philip Holland and Samuel Cooke and Alessio Delogu",

year = "2022",

month = dec,

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language = "English",

journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",

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T1 - A role for thalamic projection GABAergic neurons in circadian responses to light

AU - Brock, Olivier

AU - Gelegen, Cigdem

AU - Sully, Peter

AU - Salgarella, Irene

AU - Jager, Polona

AU - Menage, Lucy

AU - Mehta, Ishita

AU - Jęczmień-Łazur, Jagoda

AU - Djama, Deyl

AU - Strother, Lauren

AU - Coculla, Angelica

AU - Vernon, Anthony

AU - Brickley, Stephen G.

AU - Holland, Philip

AU - Cooke, Samuel

AU - Delogu, Alessio

PY - 2022/12/7

Y1 - 2022/12/7

N2 - The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex. Here, we have harnessed recent insight into the development of the intergeniculate leaflet (IGL) and the ventral lateral geniculate nucleus (LGv) to specifically target and manipulate thalamic projection GABAergic neurons in female and male mice. Our results show that thalamic GABAergic neurons of the IGL and LGv receive retinal input from diverse classes of retinal ganglion cells (RGCs) but not from the M1 intrinsically photosensitive retinal ganglion cell (ipRGC) type. We describe the synergistic role of the photoreceptor melanopsin and the thalamic neurons of the IGL/LGv in circadian entrainment to dim light. We identify a requirement for the thalamic IGL/LGv neurons in the rapid changes in vigilance states associated with circadian light transitions.

AB - The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex. Here, we have harnessed recent insight into the development of the intergeniculate leaflet (IGL) and the ventral lateral geniculate nucleus (LGv) to specifically target and manipulate thalamic projection GABAergic neurons in female and male mice. Our results show that thalamic GABAergic neurons of the IGL and LGv receive retinal input from diverse classes of retinal ganglion cells (RGCs) but not from the M1 intrinsically photosensitive retinal ganglion cell (ipRGC) type. We describe the synergistic role of the photoreceptor melanopsin and the thalamic neurons of the IGL/LGv in circadian entrainment to dim light. We identify a requirement for the thalamic IGL/LGv neurons in the rapid changes in vigilance states associated with circadian light transitions.

M3 - Article

SN - 1529-2401

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

ER -

A role for thalamic projection GABAergic neurons in circadian responses to light

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A role for thalamic projection GABAergic neurons in circadian responses to light

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