A sensitivity analysis on 3D velocity reconstruction from multiple registered echo Doppler views

TY - JOUR

T1 - A sensitivity analysis on 3D velocity reconstruction from multiple registered echo Doppler views

AU - Gomez Herrero, Alberto

AU - Pushparajah, Kuberan

AU - Simpson, John M

AU - Giese, Daniel

AU - Schaeffter, Tobias

AU - Penney, Graeme

PY - 2013/8

Y1 - 2013/8

N2 - We present a new method for reconstructing a 3D+t velocity field from multiple 3D+t colour Doppler images. Our technique reconstructs 3D velocity vectors from registered multiple standard 3D colour Doppler views, each of which contains a 1D projection of the blood velocity. Reconstruction is based on a scalable patch-wise Least Mean Squares approach, and a continuous velocity field is achieved by using a B-spline grid.We carry out a sensitivity analysis of clinically relevant parameters which affect the accuracy of the reconstruction, including the impact of noise, view angles and registration errors, using simulated data. A realistic simulation framework is achieved by a novel noise model to represent variations in colour Doppler images based on multiscale additive Gaussian noise. Simulations show that, if the Target Registration Error <2.5mm, view angles are >20° and the standard deviation of noise in the input data is <10cm/s, the reconstructed velocity field presents visually plausible flow patterns and mean error in flow rate is approximately 10% compared to 2D+t Flow MRI. These results are verified by reconstructing 3D velocity on 3 healthy volunteers. The technique is applied to reconstruct 3D flow on three paediatric patients showing promising results for clinical application.

AB - We present a new method for reconstructing a 3D+t velocity field from multiple 3D+t colour Doppler images. Our technique reconstructs 3D velocity vectors from registered multiple standard 3D colour Doppler views, each of which contains a 1D projection of the blood velocity. Reconstruction is based on a scalable patch-wise Least Mean Squares approach, and a continuous velocity field is achieved by using a B-spline grid.We carry out a sensitivity analysis of clinically relevant parameters which affect the accuracy of the reconstruction, including the impact of noise, view angles and registration errors, using simulated data. A realistic simulation framework is achieved by a novel noise model to represent variations in colour Doppler images based on multiscale additive Gaussian noise. Simulations show that, if the Target Registration Error <2.5mm, view angles are >20° and the standard deviation of noise in the input data is <10cm/s, the reconstructed velocity field presents visually plausible flow patterns and mean error in flow rate is approximately 10% compared to 2D+t Flow MRI. These results are verified by reconstructing 3D velocity on 3 healthy volunteers. The technique is applied to reconstruct 3D flow on three paediatric patients showing promising results for clinical application.

KW - Colour Doppler echocardiography

KW - 3D velocity reconstruction

KW - Flow patterns

KW - Multiple views

KW - Image registration

KW - ASCENDING AORTA

KW - ULTRASOUND

KW - FLOW

KW - ECHOCARDIOGRAPHY

KW - VISUALIZATION

KW - ACCURACY

KW - IMAGES

U2 - 10.1016/j.media.2013.04.002

DO - 10.1016/j.media.2013.04.002

M3 - Article

C2 - 23708254

SN - 1361-8415

VL - 17

SP - 616

EP - 631

JO - Medical Image Analysis

JF - Medical Image Analysis

IS - 6

ER -