A short dynamic scan method of measuring bone metabolic flux using [¹⁸ f]naf pet

TY - JOUR

T1 - A short dynamic scan method of measuring bone metabolic flux using [18 f]naf pet

AU - Puri, Tanuj

AU - Siddique, Musib M.

AU - Frost, Michelle L.

AU - Moore, Amelia E.B.

AU - Blake, Glen M.

N1 - Funding Information: Funding: The data were obtained as part of a research grant funded by Novartis Pharma. This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St. Thomas’ NHS Foundation Trust and King’s College London. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/12

Y1 - 2021/12

N2 - [18 F]NaF PET measurements of bone metabolic flux (Ki) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we evaluated and compared measurements of Ki with shorter scan times analysed with fixed values of the Hawkins model rate constants. The scans were acquired in a trial in 30 postmenopausal women, half treated with teriparatide (TPT) and half untreated. Sixty-minute PET-CT scans of both hips were acquired at baseline and week 12 after injection with 180 MBq [18 F]NaF. Scans were analysed using the Hawkins model by fitting bone time–activity curves at seven volumes of interest (VOIs) with a semi-population arterial input function. The model was re-run with fixed rate-constants for dynamic scan times from 0–12 min increasing in 4-min steps up to 0–60 min. Using the Hawkins model with fixed rateconstants, Ki measurements with statistical power equivalent or superior to conventionally analysed 60-min dynamic scans were obtained with scan times as short as 12 min.

AB - [18 F]NaF PET measurements of bone metabolic flux (Ki) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we evaluated and compared measurements of Ki with shorter scan times analysed with fixed values of the Hawkins model rate constants. The scans were acquired in a trial in 30 postmenopausal women, half treated with teriparatide (TPT) and half untreated. Sixty-minute PET-CT scans of both hips were acquired at baseline and week 12 after injection with 180 MBq [18 F]NaF. Scans were analysed using the Hawkins model by fitting bone time–activity curves at seven volumes of interest (VOIs) with a semi-population arterial input function. The model was re-run with fixed rate-constants for dynamic scan times from 0–12 min increasing in 4-min steps up to 0–60 min. Using the Hawkins model with fixed rateconstants, Ki measurements with statistical power equivalent or superior to conventionally analysed 60-min dynamic scans were obtained with scan times as short as 12 min.

KW - Arterial input function

KW - Bone metabolism

KW - Computed tomography

KW - CT

KW - Kinetic modelling

KW - PET

KW - Positron emission tomography

KW - Short dynamic scan

KW - [ F] sodium fluoride

KW - [ F]NaF

UR - http://www.scopus.com/inward/record.url?scp=85118128462&partnerID=8YFLogxK

U2 - 10.3390/tomography7040053

DO - 10.3390/tomography7040053

M3 - Article

AN - SCOPUS:85118128462

SN - 2379-1381

VL - 7

SP - 623

EP - 635

JO - Tomography

JF - Tomography

IS - 4

ER -