A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Stephanie Kullmann; Lore Wagner; Robert Hauffe; Anne Kühnel; Leontine Sandforth; Ralf Veit; Corinna Dannecker; Jürgen Machann; Andreas Fritsche; Nobert Stefan; Hubert Preissl; Nils B Kroemer; Martin Heni; André Kleinridders; Andreas L Birkenfeld

doi:10.1038/s42255-025-01226-9

A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Stephanie Kullmann, Lore Wagner, Robert Hauffe, Anne Kühnel, Leontine Sandforth, Ralf Veit, Corinna Dannecker, Jürgen Machann, Andreas Fritsche, Nobert Stefan, Hubert Preissl, Nils B Kroemer, Martin Heni, André Kleinridders, Andreas L Birkenfeld

SCMMS Denmark Hill

Research output: Contribution to journal › Article › peer-review

Abstract

Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

Original language	English
Article number	e12934
Pages (from-to)	469-477
Number of pages	9
Journal	Nature Metabolism
Volume	7
Issue number	3
Early online date	21 Feb 2025
DOIs	https://doi.org/10.1038/s42255-025-01226-9
Publication status	Published - Mar 2025

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10.1038/s42255-025-01226-9Licence: CC BY

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Kullmann, S., Wagner, L., Hauffe, R., Kühnel, A., Sandforth, L., Veit, R., Dannecker, C., Machann, J., Fritsche, A., Stefan, N., Preissl, H., Kroemer, N. B., Heni, M., Kleinridders, A., & Birkenfeld, A. L. (2025). A short-term, high-caloric diet has prolonged effects on brain insulin action in men. Nature Metabolism, 7(3), 469-477. Article e12934. https://doi.org/10.1038/s42255-025-01226-9

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title = "A short-term, high-caloric diet has prolonged effects on brain insulin action in men",

abstract = "Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.",

author = "Stephanie Kullmann and Lore Wagner and Robert Hauffe and Anne K{\"u}hnel and Leontine Sandforth and Ralf Veit and Corinna Dannecker and J{\"u}rgen Machann and Andreas Fritsche and Nobert Stefan and Hubert Preissl and Kroemer, {Nils B} and Martin Heni and Andr{\'e} Kleinridders and Birkenfeld, {Andreas L}",

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Kullmann, S, Wagner, L, Hauffe, R, Kühnel, A, Sandforth, L, Veit, R, Dannecker, C, Machann, J, Fritsche, A, Stefan, N, Preissl, H, Kroemer, NB, Heni, M, Kleinridders, A & Birkenfeld, AL 2025, 'A short-term, high-caloric diet has prolonged effects on brain insulin action in men', Nature Metabolism, vol. 7, no. 3, e12934, pp. 469-477. https://doi.org/10.1038/s42255-025-01226-9

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AU - Kullmann, Stephanie

AU - Wagner, Lore

AU - Hauffe, Robert

AU - Kühnel, Anne

AU - Sandforth, Leontine

AU - Veit, Ralf

AU - Dannecker, Corinna

AU - Machann, Jürgen

AU - Fritsche, Andreas

AU - Stefan, Nobert

AU - Preissl, Hubert

AU - Kroemer, Nils B

AU - Heni, Martin

AU - Kleinridders, André

AU - Birkenfeld, Andreas L

PY - 2025/3

Y1 - 2025/3

N2 - Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

AB - Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

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JO - Nature Metabolism

JF - Nature Metabolism

IS - 3

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ER -

A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Abstract

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