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A single pot template reaction towards a manganese based T1 contrast agent

Research output: Contribution to journalArticlepeer-review

Sellamuthu Anbu, Sabrina Hoffmann, Fabio Carniato, Lawrence Kenning, Thomas Price, Timothy J. Prior, Mauro Botta, Andre F. Martins, Graeme Stasiuk

Original languageEnglish
Pages (from-to)10736-10744
Number of pages9
JournalANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume60
Issue number19
DOIs
Published3 May 2021

Bibliographical note

Funding Information: S.A. gratefully acknowledges the Departments of Chemistry and Biomedical Sciences, the University of Hull, for providing laboratory space and instruments access to carrying out this work. The work has also been partially supported by the RSC Research Fund grant (RF19‐7464). G.J.S. would like to thank the MRC for funding (MR/T002573/1). A.F.M. gratefully acknowledges the funding and support by the Swiss Werner Siemens Foundation and the Faculty of Medicine at the University of Tuebingen (Nachwuchsgruppen‐Programm). The work was also funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2180‐390900677. M.B. and F.C. are grateful to Università del Piemonte Orientale for financial support (FARC 2019). We thank also Dr. Christoph Trautwein and Georgy Berezhnoy for assistance performing H NMR and relaxometric studies at the Bruker Spectrometer 14.1 T. 1 Funding Information: S.A. gratefully acknowledges the Departments of Chemistry and Biomedical Sciences, the University of Hull, for providing laboratory space and instruments access to carrying out this work. The work has also been partially supported by the RSC Research Fund grant (RF19-7464). G.J.S. would like to thank the MRC for funding (MR/T002573/1). A.F.M. gratefully acknowledges the funding and support by the Swiss Werner Siemens Foundation and the Faculty of Medicine at the University of Tuebingen (Nachwuchsgruppen-Programm). The work was also funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy?EXC 2180-390900677. M.B. and F.C. are grateful to Universit? del Piemonte Orientale for financial support (FARC 2019). We thank also Dr. Christoph Trautwein and Georgy Berezhnoy for assistance performing 1H NMR and relaxometric studies at the Bruker Spectrometer 14.1 T. Publisher Copyright: © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, MnL Me, and studied the most important physicochemical properties in vitro. MnL Me displays optimized r 1 relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced r 1 b=21.1 mM −1 s −1 (20 MHz, 298 K, pH 7.4) upon binding to BSA (K a=4.2×10 3 M −1). In vivo studies show that MnL Me is cleared intact into the bladder through renal excretion and has a prolonged blood half-life compared to the commercial GdCA Magnevist. MnL Me shows great promise as a novel MRI contrast agent.

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