A study of glycolytic and pentose phosphate shunt enzymes in relationship to the altered permeability in the blood-brain barrier

M J Bennett; K M Ogilvy; G M Blake; N Lewtas; W R Timperley

doi:10.1111/j.1471-4159.1976.tb06997.x

A study of glycolytic and pentose phosphate shunt enzymes in relationship to the altered permeability in the blood-brain barrier

M J Bennett, K M Ogilvy, G M Blake, N Lewtas, W R Timperley

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The activities of a number of glycolytic and hexose-monophosphate shunt cnzymes in 14 cases of intracranial pathology have been compared with specific uptake of the radioactive tracer 99m Tc-pertechnetate. Strong positive correlations were observed betwcen isotope uptake and the activities of hexokinase and glucose-6-phosphate dehydrogenase. No close correlation was observed with other enzymes studied. Hexokinase is considered to be one of the major rate determining enzymes for the glycolytic catabolism of carbohydratcs and the subsequent production of nucleotidc triphophosphates which are vital in active transport mechanisms. This could indicate an important role for this enzyme in blood-brain barrier kinetics.

Original language	English
Article number	N/A
Pages (from-to)	1139-1143
Number of pages	5
Journal	Journal of Neurochemistry
Volume	26
Issue number	6
DOIs	https://doi.org/10.1111/j.1471-4159.1976.tb06997.x
Publication status	Published - Jun 1976

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10.1111/j.1471-4159.1976.tb06997.x

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title = "A study of glycolytic and pentose phosphate shunt enzymes in relationship to the altered permeability in the blood-brain barrier",

abstract = "The activities of a number of glycolytic and hexose-monophosphate shunt cnzymes in 14 cases of intracranial pathology have been compared with specific uptake of the radioactive tracer 99m Tc-pertechnetate. Strong positive correlations were observed betwcen isotope uptake and the activities of hexokinase and glucose-6-phosphate dehydrogenase. No close correlation was observed with other enzymes studied. Hexokinase is considered to be one of the major rate determining enzymes for the glycolytic catabolism of carbohydratcs and the subsequent production of nucleotidc triphophosphates which are vital in active transport mechanisms. This could indicate an important role for this enzyme in blood-brain barrier kinetics.",

author = "Bennett, {M J} and Ogilvy, {K M} and Blake, {G M} and N Lewtas and Timperley, {W R}",

year = "1976",

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doi = "10.1111/j.1471-4159.1976.tb06997.x",

language = "English",

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pages = "1139--1143",

journal = "Journal of Neurochemistry",

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T1 - A study of glycolytic and pentose phosphate shunt enzymes in relationship to the altered permeability in the blood-brain barrier

AU - Bennett, M J

AU - Ogilvy, K M

AU - Blake, G M

AU - Lewtas, N

AU - Timperley, W R

PY - 1976/6

Y1 - 1976/6

N2 - The activities of a number of glycolytic and hexose-monophosphate shunt cnzymes in 14 cases of intracranial pathology have been compared with specific uptake of the radioactive tracer 99m Tc-pertechnetate. Strong positive correlations were observed betwcen isotope uptake and the activities of hexokinase and glucose-6-phosphate dehydrogenase. No close correlation was observed with other enzymes studied. Hexokinase is considered to be one of the major rate determining enzymes for the glycolytic catabolism of carbohydratcs and the subsequent production of nucleotidc triphophosphates which are vital in active transport mechanisms. This could indicate an important role for this enzyme in blood-brain barrier kinetics.

AB - The activities of a number of glycolytic and hexose-monophosphate shunt cnzymes in 14 cases of intracranial pathology have been compared with specific uptake of the radioactive tracer 99m Tc-pertechnetate. Strong positive correlations were observed betwcen isotope uptake and the activities of hexokinase and glucose-6-phosphate dehydrogenase. No close correlation was observed with other enzymes studied. Hexokinase is considered to be one of the major rate determining enzymes for the glycolytic catabolism of carbohydratcs and the subsequent production of nucleotidc triphophosphates which are vital in active transport mechanisms. This could indicate an important role for this enzyme in blood-brain barrier kinetics.

U2 - 10.1111/j.1471-4159.1976.tb06997.x

DO - 10.1111/j.1471-4159.1976.tb06997.x

M3 - Article

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EP - 1143

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 6

M1 - N/A

ER -

A study of glycolytic and pentose phosphate shunt enzymes in relationship to the altered permeability in the blood-brain barrier

Abstract

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