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A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study.

Research output: Contribution to journalArticle

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A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study. / Price, Angeline; Barlow-Pay, Fenella; Duffy, Siobhan; Pearce, Lyndsay ; Vilches-Moraga, Arturo; Moug, Susan; Quinn, Terry J.; Stechman, Michael J; Braude, Philip; Mitchell, Emma; Myint, Phyo Kyaw; Verduri, Alessia; McCarthy, Kathryn; Carter, Ben; Hewitt, Jonathan.

In: BMJ Open, 11.09.2020.

Research output: Contribution to journalArticle

Harvard

Price, A, Barlow-Pay, F, Duffy, S, Pearce, L, Vilches-Moraga, A, Moug, S, Quinn, TJ, Stechman, MJ, Braude, P, Mitchell, E, Myint, PK, Verduri, A, McCarthy, K, Carter, B & Hewitt, J 2020, 'A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study.', BMJ Open.

APA

Price, A., Barlow-Pay, F., Duffy, S., Pearce, L., Vilches-Moraga, A., Moug, S., Quinn, T. J., Stechman, M. J., Braude, P., Mitchell, E., Myint, P. K., Verduri, A., McCarthy, K., Carter, B., & Hewitt, J. (2020). A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study. BMJ Open.

Vancouver

Price A, Barlow-Pay F, Duffy S, Pearce L, Vilches-Moraga A, Moug S et al. A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study. BMJ Open. 2020 Sep 11.

Author

Price, Angeline ; Barlow-Pay, Fenella ; Duffy, Siobhan ; Pearce, Lyndsay ; Vilches-Moraga, Arturo ; Moug, Susan ; Quinn, Terry J. ; Stechman, Michael J ; Braude, Philip ; Mitchell, Emma ; Myint, Phyo Kyaw ; Verduri, Alessia ; McCarthy, Kathryn ; Carter, Ben ; Hewitt, Jonathan. / A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study. In: BMJ Open. 2020.

Bibtex Download

@article{4f543b3c674d4628b0348156999f1628,
title = "A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study.",
abstract = "Introduction This protocol describes an observational study which set out to assess whether frailty and/or multi-morbidity correlates with short and medium term outcomes in patients diagnosed with COVID-19 in a European, multi-centre setting. The aim is to build upon available literature supporting decision making for vulnerable patient cohorts during the Covid-19 pandemic. Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across ten hospital sites, collecting baseline data including: patient demographics; presence of co-morbidities; relevant blood tests on admission; prescription of angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARBs)/ non-steroidal anti-inflammatory drugs (NSAIDs)/ immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care > 18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Our primary analysis will be short-term mortality and long-term mortality by CFS, adjusted for age (18-64, 65-80 and > 80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted hazard ratio and odds ratio with associated 95% CIs and p values. ",
author = "Angeline Price and Fenella Barlow-Pay and Siobhan Duffy and Lyndsay Pearce and Arturo Vilches-Moraga and Susan Moug and Quinn, {Terry J.} and Stechman, {Michael J} and Philip Braude and Emma Mitchell and Myint, {Phyo Kyaw} and Alessia Verduri and Kathryn McCarthy and Ben Carter and Jonathan Hewitt",
year = "2020",
month = sep,
day = "11",
language = "English",
journal = "BMJ Open",
issn = "2044-6055",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A study protocol for the COPE study: COVID-19 in Older PEople – the influence of frailty and multimorbidity on survival. A multi-centre, European observational study.

AU - Price, Angeline

AU - Barlow-Pay, Fenella

AU - Duffy, Siobhan

AU - Pearce, Lyndsay

AU - Vilches-Moraga, Arturo

AU - Moug, Susan

AU - Quinn, Terry J.

AU - Stechman, Michael J

AU - Braude, Philip

AU - Mitchell, Emma

AU - Myint, Phyo Kyaw

AU - Verduri, Alessia

AU - McCarthy, Kathryn

AU - Carter, Ben

AU - Hewitt, Jonathan

PY - 2020/9/11

Y1 - 2020/9/11

N2 - Introduction This protocol describes an observational study which set out to assess whether frailty and/or multi-morbidity correlates with short and medium term outcomes in patients diagnosed with COVID-19 in a European, multi-centre setting. The aim is to build upon available literature supporting decision making for vulnerable patient cohorts during the Covid-19 pandemic. Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across ten hospital sites, collecting baseline data including: patient demographics; presence of co-morbidities; relevant blood tests on admission; prescription of angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARBs)/ non-steroidal anti-inflammatory drugs (NSAIDs)/ immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care > 18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Our primary analysis will be short-term mortality and long-term mortality by CFS, adjusted for age (18-64, 65-80 and > 80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted hazard ratio and odds ratio with associated 95% CIs and p values.

AB - Introduction This protocol describes an observational study which set out to assess whether frailty and/or multi-morbidity correlates with short and medium term outcomes in patients diagnosed with COVID-19 in a European, multi-centre setting. The aim is to build upon available literature supporting decision making for vulnerable patient cohorts during the Covid-19 pandemic. Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across ten hospital sites, collecting baseline data including: patient demographics; presence of co-morbidities; relevant blood tests on admission; prescription of angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARBs)/ non-steroidal anti-inflammatory drugs (NSAIDs)/ immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care > 18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Our primary analysis will be short-term mortality and long-term mortality by CFS, adjusted for age (18-64, 65-80 and > 80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted hazard ratio and odds ratio with associated 95% CIs and p values.

M3 - Article

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

ER -

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