A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity disorder (ADHD) and Autism

Alessio Bellato, Luke Norman, Iman Idrees, Carolina Y. Ogawa, Alice Waitt, Pedro F. Zuccolo, Charlotte Tye, Joaquim Radua, Madeleine J. Groom, Elizabeth Shephard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Altered performance monitoring is implicated in obsessive-compulsive disorder (OCD), Gilles de la Tourette syndrome (GTS), attention-deficit/hyperactivity disorder (ADHD) and autism. We conducted a systematic review and meta-analysis of electrophysiological correlates of performance monitoring (error-related negativity, ERN; error positivity, Pe; feedback-related negativity, FRN; feedback-P3) in individuals with OCD, GTS, ADHD or autism compared to control participants, or associations between correlates and symptoms/traits of these conditions. Meta-analyses on 97 studies (5890 participants) showed increased ERN in OCD (Hedge's g = 0.54[CIs:0.44,0.65]) and GTS (g = 0.99[CIs:0.05,1.93]). OCD also showed increased Pe (g = 0.51[CIs:0.21,0.81]) and FRN (g = 0.50[CIs:0.26,0.73]). ADHD and autism showed reduced ERN (ADHD: g=-0.47[CIs:-0.67,-0.26]; autism: g=-0.61[CIs:-1.10,-0.13]). ADHD also showed reduced Pe (g=-0.50[CIs:-0.69,-0.32]). These findings suggest overlap in electrophysiological markers of performance monitoring alterations in four common neurodevelopmental conditions, with increased amplitudes of the markers in OCD and GTS and decreased amplitudes in ADHD and autism. Implications of these findings in terms of shared and distinct performance monitoring alterations across these neurodevelopmental conditions are discussed. PROSPERO pre-registration code: CRD42019134612.

Original languageEnglish
Pages (from-to)964-987
Number of pages24
JournalNeuroscience and Biobehavioral Reviews
Volume131
Early online date21 Oct 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Attention-deficit/hyperactivity disorder (ADHD)
  • Autism
  • electroencephalography (EEG)
  • error positivity (Pe)
  • error-related negativity (ERN)
  • feedback-P3
  • feedback-related negativity (FRN)
  • Gilles de la Tourette Syndrome (GTS)
  • Obsessive-compulsive disorder (OCD)

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