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A systems biology approach for studying neurodegenerative diseases

Research output: Contribution to journalReview article

Simon Lam, Abdulahad Bayraktar, Cheng Zhang, Hasan Turkez, Jens Nielsen, Jan Boren, Saeed Shoaie, Mathias Uhlen, Adil Mardinoglu

Original languageEnglish
Pages (from-to)1146-1159
Number of pages14
JournalDRUG DISCOVERY TODAY
Volume25
Issue number7
DOIs
PublishedJul 2020

King's Authors

Abstract

Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.

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