Research output: Contribution to journal › Review article › peer-review
Simon Lam, Abdulahad Bayraktar, Cheng Zhang, Hasan Turkez, Jens Nielsen, Jan Boren, Saeed Shoaie, Mathias Uhlen, Adil Mardinoglu
Original language | English |
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Pages (from-to) | 1146-1159 |
Number of pages | 14 |
Journal | DRUG DISCOVERY TODAY |
Volume | 25 |
Issue number | 7 |
DOIs | |
Published | Jul 2020 |
Additional links |
Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.
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