A systems medicine research approach for studying alcohol addiction

Rainer Spanagel; Daniel Durstewitz; Anita Hansson; Andreas Heinz; Falk Kiefer; Georg Kohr; Franziska Matthäus; Gunter Schumann; Michael N. Smolka; Markus M. Nöthen; Hamid R. Noori; Klaus Obermayer; Marcella Rietschel; Patrick Schloss; Henrike Scholz; Wolfgang Sommer; Valentina Vengeliene; Henrik Walter; Wolfgang Wurst; Uli S. Zimmermann; Addiction GWAS Resource Group; Sven Stringer; Yannick Smits; Eske M. Derks

doi:10.1111/adb.12109

A systems medicine research approach for studying alcohol addiction

Rainer Spanagel, Daniel Durstewitz, Anita Hansson, Andreas Heinz, Falk Kiefer, Georg Kohr, Franziska Matthäus, Gunter Schumann, Michael N. Smolka, Markus M. Nöthen, Hamid R. Noori, Klaus Obermayer, Marcella Rietschel, Patrick Schloss, Henrike Scholz, Wolfgang Sommer, Valentina Vengeliene, Henrik Walter, Wolfgang Wurst, Uli S. ZimmermannAddiction GWAS Resource Group, Sven Stringer, Yannick Smits, Eske M. Derks

Research output: Contribution to journal › Book/Film/Article review › peer-review

77 Citations (Scopus)

Abstract

According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health‐care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics‐information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann et al. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

Original language	English
Pages (from-to)	883-896
Number of pages	14
Journal	Addiction Biology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1111/adb.12109
Publication status	Published - Nov 2013

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10.1111/adb.12109

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Spanagel, R., Durstewitz, D., Hansson, A., Heinz, A., Kiefer, F., Kohr, G., Matthäus, F., Schumann, G., Smolka, M. N., Nöthen, M. M., Noori, H. R., Obermayer, K., Rietschel, M., Schloss, P., Scholz, H., Sommer, W., Vengeliene, V., Walter, H., Wurst, W., ... Derks, E. M. (2013). A systems medicine research approach for studying alcohol addiction. Addiction Biology, 18(6), 883-896. https://doi.org/10.1111/adb.12109

@article{50f77f50b39344ed8061778cc597b38d,

title = "A systems medicine research approach for studying alcohol addiction",

abstract = "According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health‐care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics‐information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann et al. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.",

author = "Rainer Spanagel and Daniel Durstewitz and Anita Hansson and Andreas Heinz and Falk Kiefer and Georg Kohr and Franziska Matth{\"a}us and Gunter Schumann and Smolka, {Michael N.} and N{\"o}then, {Markus M.} and Noori, {Hamid R.} and Klaus Obermayer and Marcella Rietschel and Patrick Schloss and Henrike Scholz and Wolfgang Sommer and Valentina Vengeliene and Henrik Walter and Wolfgang Wurst and Zimmermann, {Uli S.} and {Addiction GWAS Resource Group} and Sven Stringer and Yannick Smits and Derks, {Eske M.}",

year = "2013",

month = nov,

doi = "10.1111/adb.12109",

language = "English",

volume = "18",

pages = "883--896",

journal = "Addiction Biology",

issn = "1355-6215",

publisher = "Wiley-Blackwell",

number = "6",

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Spanagel, R, Durstewitz, D, Hansson, A, Heinz, A, Kiefer, F, Kohr, G, Matthäus, F, Schumann, G, Smolka, MN, Nöthen, MM, Noori, HR, Obermayer, K, Rietschel, M, Schloss, P, Scholz, H, Sommer, W, Vengeliene, V, Walter, H, Wurst, W, Zimmermann, US, Addiction GWAS Resource Group, Stringer, S, Smits, Y & Derks, EM 2013, 'A systems medicine research approach for studying alcohol addiction', Addiction Biology, vol. 18, no. 6, pp. 883-896. https://doi.org/10.1111/adb.12109

TY - JOUR

T1 - A systems medicine research approach for studying alcohol addiction

AU - Spanagel, Rainer

AU - Durstewitz, Daniel

AU - Hansson, Anita

AU - Heinz, Andreas

AU - Kiefer, Falk

AU - Kohr, Georg

AU - Matthäus, Franziska

AU - Schumann, Gunter

AU - Smolka, Michael N.

AU - Nöthen, Markus M.

AU - Noori, Hamid R.

AU - Obermayer, Klaus

AU - Rietschel, Marcella

AU - Schloss, Patrick

AU - Scholz, Henrike

AU - Sommer, Wolfgang

AU - Vengeliene, Valentina

AU - Walter, Henrik

AU - Wurst, Wolfgang

AU - Zimmermann, Uli S.

AU - Addiction GWAS Resource Group

AU - Stringer, Sven

AU - Smits, Yannick

AU - Derks, Eske M.

PY - 2013/11

Y1 - 2013/11

N2 - According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health‐care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics‐information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann et al. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

AB - According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health‐care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics‐information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann et al. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

U2 - 10.1111/adb.12109

DO - 10.1111/adb.12109

M3 - Book/Film/Article review

SN - 1355-6215

VL - 18

SP - 883

EP - 896

JO - Addiction Biology

JF - Addiction Biology

IS - 6

ER -

A systems medicine research approach for studying alcohol addiction

Abstract

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