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A Tale of two Networks-Glial Contributions to Generalized Seizures

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A Tale of two Networks-Glial Contributions to Generalized Seizures. / Rosch, Richard E; Dulla, Chris G.

In: Epilepsy Currents, Vol. 20, No. 2, 1535759720906115, 01.03.2020, p. 108-110.

Research output: Contribution to journalComment/debate

Harvard

Rosch, RE & Dulla, CG 2020, 'A Tale of two Networks-Glial Contributions to Generalized Seizures', Epilepsy Currents, vol. 20, no. 2, 1535759720906115, pp. 108-110. https://doi.org/10.1177/1535759720906115

APA

Rosch, R. E., & Dulla, C. G. (2020). A Tale of two Networks-Glial Contributions to Generalized Seizures. Epilepsy Currents, 20(2), 108-110. [1535759720906115]. https://doi.org/10.1177/1535759720906115

Vancouver

Rosch RE, Dulla CG. A Tale of two Networks-Glial Contributions to Generalized Seizures. Epilepsy Currents. 2020 Mar 1;20(2):108-110. 1535759720906115. https://doi.org/10.1177/1535759720906115

Author

Rosch, Richard E ; Dulla, Chris G. / A Tale of two Networks-Glial Contributions to Generalized Seizures. In: Epilepsy Currents. 2020 ; Vol. 20, No. 2. pp. 108-110.

Bibtex Download

@article{4989faa43f9840c7955ca010d4993771,
title = "A Tale of two Networks-Glial Contributions to Generalized Seizures",
abstract = "Glia-Neuron Interactions Underlie State Transitions to Generalized Seizures Diaz Verdugo C, Myren-Svelstad S, Aydin E, et al. Nat Commun. 2019;10:3830. doi:10.1038/s41467-019-11739-z. Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions and a massive increase in extracellular glutamate. Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia–glia and glia–neuron connections in the generation of epileptic seizures.",
author = "Rosch, {Richard E} and Dulla, {Chris G}",
year = "2020",
month = "3",
day = "1",
doi = "10.1177/1535759720906115",
language = "English",
volume = "20",
pages = "108--110",
journal = "Epilepsy Currents",
issn = "1535-7597",
publisher = "American Epilepsy Society",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A Tale of two Networks-Glial Contributions to Generalized Seizures

AU - Rosch, Richard E

AU - Dulla, Chris G

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Glia-Neuron Interactions Underlie State Transitions to Generalized Seizures Diaz Verdugo C, Myren-Svelstad S, Aydin E, et al. Nat Commun. 2019;10:3830. doi:10.1038/s41467-019-11739-z. Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions and a massive increase in extracellular glutamate. Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia–glia and glia–neuron connections in the generation of epileptic seizures.

AB - Glia-Neuron Interactions Underlie State Transitions to Generalized Seizures Diaz Verdugo C, Myren-Svelstad S, Aydin E, et al. Nat Commun. 2019;10:3830. doi:10.1038/s41467-019-11739-z. Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions and a massive increase in extracellular glutamate. Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia–glia and glia–neuron connections in the generation of epileptic seizures.

UR - http://www.scopus.com/inward/record.url?scp=85081538666&partnerID=8YFLogxK

U2 - 10.1177/1535759720906115

DO - 10.1177/1535759720906115

M3 - Comment/debate

C2 - 32100552

VL - 20

SP - 108

EP - 110

JO - Epilepsy Currents

JF - Epilepsy Currents

SN - 1535-7597

IS - 2

M1 - 1535759720906115

ER -

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