A terminal affair: 3 '-end recognition by the human La protein

TY - JOUR

T1 - A terminal affair: 3 '-end recognition by the human La protein

AU - Curry, S

AU - Conte, M R

PY - 2006/6

Y1 - 2006/6

N2 - The La protein, an autoantigen in rheumatic disease, orchestrates several aspects of the metabolism of noncoding RNA molecules. More than 20 years ago it was shown that La primarily binds the 3' UUU-OH tails of nascent transcripts of RNA polymerase Ill. A recent study now reveals how the structure of the amino-terminal domain of the human La protein achieves specific 3'-end recognition

AB - The La protein, an autoantigen in rheumatic disease, orchestrates several aspects of the metabolism of noncoding RNA molecules. More than 20 years ago it was shown that La primarily binds the 3' UUU-OH tails of nascent transcripts of RNA polymerase Ill. A recent study now reveals how the structure of the amino-terminal domain of the human La protein achieves specific 3'-end recognition

U2 - 10.1016/j.tibs.2006.04.008

DO - 10.1016/j.tibs.2006.04.008

M3 - Article

SN - 0968-0004

VL - 31

SP - 303

EP - 305

JO - TRENDS IN BIOCHEMICAL SCIENCES

JF - TRENDS IN BIOCHEMICAL SCIENCES

IS - 6

ER -