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A three-dimensional model of canine cardiac ventricular wall electrophysiology

Research output: Contribution to journalConference paper

A.P. Benson, Oleg Aslanidi, H. Zhang, A.V. Holden

Original languageEnglish
Pages (from-to)789-792
Number of pages4
JournalComputing in Cardiology
Volume33
Published1 Jan 2006

King's Authors

Abstract

We have developed a three-dimensional computational wedge model of canine cardiac ventricular wall electrophysiology that incorporates biophysically detailed, spatially heterogeneous excitation, and high-resolution geometry and fibre orientation. Isolated cell model electrophysiological characteristics reproduce the experimentally observed characteristics under control conditions, and under conditions of bradycardia, with the application of a class III antiarrhythmic drug, and during simulation of long-QT syndrome 2. Propagation of excitation through the ventricular wall and the subsequent dispersion of repolarisation also reproduce experimentally observed behaviour under the same four conditions. The model therefore provides a tool for the computational study of the mechanisms underlying cardiac arrhythmias.

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