A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

Sumoyee Basu; Anthony Dorling; Anita S. Chong

doi:10.1016/j.kint.2022.12.020

A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

Sumoyee Basu, Anthony Dorling^*, Anita S. Chong

^*Corresponding author for this work

Inflammation Biology

Research output: Contribution to journal › Comment/debate › peer-review

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Abstract

Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-α, which identifies patients at high risk for poor outcomes. The potential mechanisms by which transitional T1 B cells might modulate alloreactivity need exploration, but following appropriate validation, this biomarker could risk stratify patients in need of early intervention.

Original language	English
Pages (from-to)	658-660
Number of pages	3
Journal	Kidney International
Volume	103
Issue number	4
Early online date	20 Mar 2023
DOIs	https://doi.org/10.1016/j.kint.2022.12.020
Publication status	Published - Apr 2023

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10.1016/j.kint.2022.12.020

A transitional B cell cytokine_BASU_Accepted21December2022_GREEN Accepted author manuscript, 189 KBLicence: CC BY-NC-ND

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A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

Abstract

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