A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

TY - JOUR

T1 - A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

AU - Basu, Sumoyee

AU - Dorling, Anthony

AU - Chong, Anita S.

N1 - Publisher Copyright: © 2023 International Society of Nephrology

PY - 2023/4

Y1 - 2023/4

N2 - Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-α, which identifies patients at high risk for poor outcomes. The potential mechanisms by which transitional T1 B cells might modulate alloreactivity need exploration, but following appropriate validation, this biomarker could risk stratify patients in need of early intervention.

AB - Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-α, which identifies patients at high risk for poor outcomes. The potential mechanisms by which transitional T1 B cells might modulate alloreactivity need exploration, but following appropriate validation, this biomarker could risk stratify patients in need of early intervention.

UR - https://www.scopus.com/pages/publications/85150361319

U2 - 10.1016/j.kint.2022.12.020

DO - 10.1016/j.kint.2022.12.020

M3 - Comment/debate

SN - 0085-2538

VL - 103

SP - 658

EP - 660

JO - Kidney International

JF - Kidney International

IS - 4

ER -