TY - JOUR
T1 - A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
AU - Jiang, Dai
AU - Liu, Fangqi
AU - Lancashire, Henry T.
AU - Perkins, Timothy A.
AU - Schormans, Matthew
AU - Vanhoestenberghe, Anne
AU - Donaldson, Nicholas De N.
AU - Demosthenous, Andreas
N1 - Funding Information:
This work was supported in part by the European Commission under projects NEUWalk and CLONS (agreement numbers 258654 and 225929). The open access publication fees were provided by University College London.
Funding Information:
The authors would like to thank Prof. David Borton from Brown University for the discussions on the device specifications and Dr. Peter Detemple from Fraunhofer IMM for providing the epidural electrode array for the in vitro evaluation. Funding. This work was supported in part by the European Commission under projects NEUWalk and CLONS (agreement numbers 258654 and 225929). The open access publication fees were provided by University College London.
Publisher Copyright:
© Copyright © 2021 Jiang, Liu, Lancashire, Perkins, Schormans, Vanhoestenberghe, Donaldson and Demosthenous.
PY - 2021/7/22
Y1 - 2021/7/22
N2 - This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.
AB - This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.
KW - hermetic seal package
KW - implantable stimulator
KW - microelectronics
KW - power and data telemetry
KW - wireless stimulation control
UR - http://www.scopus.com/inward/record.url?scp=85112623732&partnerID=8YFLogxK
U2 - 10.3389/fnins.2021.681021
DO - 10.3389/fnins.2021.681021
M3 - Article
SN - 1662-453X
VL - 15
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 681021
ER -