AAV2 Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome

Michael Seyffert, Daniel L Glauser, Kurt Tobler, Oleg Georgiev, Rebecca Vogel, Bernd Vogt, Leticia Agúndez, Michael Linden, Hildegard Büning, Mathias Ackermann, Cornel Fraefel

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Adeno-associated virus type-2 is known to inhibit replication of herpes simplex virus type-1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep-helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/78 to the HSV-1 genome.
Original languageEnglish
JournalJournal of Virology
DOIs
Publication statusE-pub ahead of print - 19 Aug 2015

Fingerprint

Dive into the research topics of 'AAV2 Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome'. Together they form a unique fingerprint.

Cite this