Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment

Valeria Mondelli; Paola Dazzan; Nilay Hepgul; Marta Di Forti; Monica Aas; Alessandro D'Albenzio; Marco Di Nicola; Helen Fisher; Rowena Handley; Tiago Reis Marques; Craig Morgan; Serena Navari; Heather Taylor; Andrew Papadopoulos; Katherine J. Aitchison; Robin M. Murray; Carmine M. Pariante

doi:10.1016/j.schres.2009.08.013

Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment

Valeria Mondelli, Paola Dazzan, Nilay Hepgul, Marta Di Forti, Monica Aas, Alessandro D'Albenzio, Marco Di Nicola, Helen Fisher, Rowena Handley, Tiago Reis Marques, Craig Morgan, Serena Navari, Heather Taylor, Andrew Papadopoulos, Katherine J. Aitchison, Robin M. Murray, Carmine M. Pariante

Research output: Contribution to journal › Article › peer-review

239 Citations (Scopus)

Abstract

First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study was to investigate the role of stress and antipsychotic treatment on diurnal cortisol levels, and on cortisol awakening response, in FEP. Recent stressful events, perceived stress and childhood trauma were collected in 50 FEP patients and 36 healthy controls using structured instruments. Salivary cortisol was obtained at awakening, at 15, 30, and 60 min after awakening, and at 12 and 8 pm. Patients experienced more recent stressful events, perceived stress and childhood trauma than controls (p

Original language	English
Pages (from-to)	234 - 242
Number of pages	9
Journal	Schizophrenia Research
Volume	116
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2009.08.013
Publication status	Published - Feb 2010

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Mondelli, V., Dazzan, P., Hepgul, N., Di Forti, M., Aas, M., D'Albenzio, A., Di Nicola, M., Fisher, H., Handley, R., Marques, T. R., Morgan, C., Navari, S., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R. M., & Pariante, C. M. (2010). Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment. Schizophrenia Research, 116(2-3), 234 - 242. https://doi.org/10.1016/j.schres.2009.08.013

@article{65b76f23b6114d7a84eeb5f4eff099ad,

title = "Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment",

abstract = "First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study was to investigate the role of stress and antipsychotic treatment on diurnal cortisol levels, and on cortisol awakening response, in FEP. Recent stressful events, perceived stress and childhood trauma were collected in 50 FEP patients and 36 healthy controls using structured instruments. Salivary cortisol was obtained at awakening, at 15, 30, and 60 min after awakening, and at 12 and 8 pm. Patients experienced more recent stressful events, perceived stress and childhood trauma than controls (p",

author = "Valeria Mondelli and Paola Dazzan and Nilay Hepgul and {Di Forti}, Marta and Monica Aas and Alessandro D'Albenzio and {Di Nicola}, Marco and Helen Fisher and Rowena Handley and Marques, {Tiago Reis} and Craig Morgan and Serena Navari and Heather Taylor and Andrew Papadopoulos and Aitchison, {Katherine J.} and Murray, {Robin M.} and Pariante, {Carmine M.}",

year = "2010",

month = feb,

doi = "10.1016/j.schres.2009.08.013",

language = "English",

volume = "116",

pages = "234 -- 242",

journal = "Schizophrenia Research",

issn = "1573-2509",

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Mondelli, V , Dazzan, P , Hepgul, N , Di Forti, M , Aas, M, D'Albenzio, A, Di Nicola, M, Fisher, H, Handley, R, Marques, TR, Morgan, C, Navari, S, Taylor, H, Papadopoulos, A, Aitchison, KJ , Murray, RM & Pariante, CM 2010, 'Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment', Schizophrenia Research, vol. 116, no. 2-3, pp. 234 - 242. https://doi.org/10.1016/j.schres.2009.08.013

TY - JOUR

T1 - Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment

AU - Mondelli, Valeria

AU - Dazzan, Paola

AU - Hepgul, Nilay

AU - Di Forti, Marta

AU - Aas, Monica

AU - D'Albenzio, Alessandro

AU - Di Nicola, Marco

AU - Fisher, Helen

AU - Handley, Rowena

AU - Marques, Tiago Reis

AU - Morgan, Craig

AU - Navari, Serena

AU - Taylor, Heather

AU - Papadopoulos, Andrew

AU - Aitchison, Katherine J.

AU - Murray, Robin M.

AU - Pariante, Carmine M.

PY - 2010/2

Y1 - 2010/2

N2 - First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study was to investigate the role of stress and antipsychotic treatment on diurnal cortisol levels, and on cortisol awakening response, in FEP. Recent stressful events, perceived stress and childhood trauma were collected in 50 FEP patients and 36 healthy controls using structured instruments. Salivary cortisol was obtained at awakening, at 15, 30, and 60 min after awakening, and at 12 and 8 pm. Patients experienced more recent stressful events, perceived stress and childhood trauma than controls (p

AB - First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study was to investigate the role of stress and antipsychotic treatment on diurnal cortisol levels, and on cortisol awakening response, in FEP. Recent stressful events, perceived stress and childhood trauma were collected in 50 FEP patients and 36 healthy controls using structured instruments. Salivary cortisol was obtained at awakening, at 15, 30, and 60 min after awakening, and at 12 and 8 pm. Patients experienced more recent stressful events, perceived stress and childhood trauma than controls (p

U2 - 10.1016/j.schres.2009.08.013

DO - 10.1016/j.schres.2009.08.013

M3 - Article

SN - 1573-2509

VL - 116

SP - 234

EP - 242

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment

Abstract

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