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Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients

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Björn C. Frye, Laura Potasso, Erik Farin, Urs Fichtner, Surrinder Birring, Joachim Müller-Quernheim, Jonas Christian Schupp

Original languageEnglish
Article number106600
JournalRespiratory medicine
PublishedNov 2021

Bibliographical note

Funding Information: This study has been funded by intramural fundings of the University of Freiburg. Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


Sarcoidosis is a granulomatous disease that mainly manifests within the lungs and may thereby impair lung function. Beyond and independently from organ impairment, sarcoidosis may affect quality of life which can be quantified by questionnaires. The Leicester Cough Questionnaire (LCQ) has been developed to assess cough-related quality of life. We analysed data from a prospectively collected cohort of sarcoidosis patients for validation of the German LCQ version. Our analyses demonstrated that LCQ values add additional information beyond routinely monitored parameters (e.g. lung function). Only FeV1 and BMI slightly influence LCQ scores, where all other parameters tested did not correlate with LCQ scores. In summary, LCQ is a valuable tool providing information on the patient’ quality of life beyond routine follow-up parameters. FeV1 and BMI may represent treatable traits to reduce cough-related disease burden.

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